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Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer

BACKGROUND: The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics of CTCs are poorly understood. METHODS: A total of 87 patients with metastatic or recurrent GI cancer were prospectively...

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Detalles Bibliográficos
Autores principales: Iwatsuki, M, Toyoshima, K, Watanabe, M, Hayashi, N, Ishimoto, T, Eto, K, Iwagami, S, Baba, Y, Yoshida, N, Hayashi, A, Ohta, Y, Baba, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844922/
https://www.ncbi.nlm.nih.gov/pubmed/24201755
http://dx.doi.org/10.1038/bjc.2013.680
Descripción
Sumario:BACKGROUND: The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics of CTCs are poorly understood. METHODS: A total of 87 patients with metastatic or recurrent GI cancer were prospectively enrolled. Circulating tumour cells and their HER2 status were assessed using the CellSearch System. RESULTS: Among the 62 CTC-positive cases, we found 22 discordant cases (35.5%). Among the HER2-negative primary tumours, 17 of 54 developed HER2-positive CTCs. Five of eight had HER2-negative CTCs among the HER2-positive primary tumours. CONCLUSION: The findings in the current study suggest that it is critical to evaluate the HER2 status of not only the primary tumour but also the CTCs because the metastasising tumour cells are the primary target of systemic therapy.