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Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer
BACKGROUND: The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics of CTCs are poorly understood. METHODS: A total of 87 patients with metastatic or recurrent GI cancer were prospectively...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844922/ https://www.ncbi.nlm.nih.gov/pubmed/24201755 http://dx.doi.org/10.1038/bjc.2013.680 |
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author | Iwatsuki, M Toyoshima, K Watanabe, M Hayashi, N Ishimoto, T Eto, K Iwagami, S Baba, Y Yoshida, N Hayashi, A Ohta, Y Baba, H |
author_facet | Iwatsuki, M Toyoshima, K Watanabe, M Hayashi, N Ishimoto, T Eto, K Iwagami, S Baba, Y Yoshida, N Hayashi, A Ohta, Y Baba, H |
author_sort | Iwatsuki, M |
collection | PubMed |
description | BACKGROUND: The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics of CTCs are poorly understood. METHODS: A total of 87 patients with metastatic or recurrent GI cancer were prospectively enrolled. Circulating tumour cells and their HER2 status were assessed using the CellSearch System. RESULTS: Among the 62 CTC-positive cases, we found 22 discordant cases (35.5%). Among the HER2-negative primary tumours, 17 of 54 developed HER2-positive CTCs. Five of eight had HER2-negative CTCs among the HER2-positive primary tumours. CONCLUSION: The findings in the current study suggest that it is critical to evaluate the HER2 status of not only the primary tumour but also the CTCs because the metastasising tumour cells are the primary target of systemic therapy. |
format | Online Article Text |
id | pubmed-3844922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38449222014-11-26 Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer Iwatsuki, M Toyoshima, K Watanabe, M Hayashi, N Ishimoto, T Eto, K Iwagami, S Baba, Y Yoshida, N Hayashi, A Ohta, Y Baba, H Br J Cancer Short Communication BACKGROUND: The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics of CTCs are poorly understood. METHODS: A total of 87 patients with metastatic or recurrent GI cancer were prospectively enrolled. Circulating tumour cells and their HER2 status were assessed using the CellSearch System. RESULTS: Among the 62 CTC-positive cases, we found 22 discordant cases (35.5%). Among the HER2-negative primary tumours, 17 of 54 developed HER2-positive CTCs. Five of eight had HER2-negative CTCs among the HER2-positive primary tumours. CONCLUSION: The findings in the current study suggest that it is critical to evaluate the HER2 status of not only the primary tumour but also the CTCs because the metastasising tumour cells are the primary target of systemic therapy. Nature Publishing Group 2013-11-26 2013-11-07 /pmc/articles/PMC3844922/ /pubmed/24201755 http://dx.doi.org/10.1038/bjc.2013.680 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Short Communication Iwatsuki, M Toyoshima, K Watanabe, M Hayashi, N Ishimoto, T Eto, K Iwagami, S Baba, Y Yoshida, N Hayashi, A Ohta, Y Baba, H Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
title | Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
title_full | Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
title_fullStr | Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
title_full_unstemmed | Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
title_short | Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
title_sort | frequency of her2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844922/ https://www.ncbi.nlm.nih.gov/pubmed/24201755 http://dx.doi.org/10.1038/bjc.2013.680 |
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