Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease

Malfunctioning of the protein α-synuclein is critically involved in the demise of dopaminergic neurons relevant to Parkinson’s disease. Nonetheless, the precise mechanisms explaining this pathogenic neuronal cell death remain elusive. Endonuclease G (EndoG) is a mitochondrially localized nuclease th...

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Detalles Bibliográficos
Autores principales: Büttner, Sabrina, Habernig, Lukas, Broeskamp, Filomena, Ruli, Doris, Vögtle, F Nora, Vlachos, Manolis, Macchi, Francesca, Küttner, Victoria, Carmona-Gutierrez, Didac, Eisenberg, Tobias, Ring, Julia, Markaki, Maria, Taskin, Asli Aras, Benke, Stefan, Ruckenstuhl, Christoph, Braun, Ralf, Van den Haute, Chris, Bammens, Tine, van der Perren, Anke, Fröhlich, Kai-Uwe, Winderickx, Joris, Kroemer, Guido, Baekelandt, Veerle, Tavernarakis, Nektarios, Kovacs, Gabor G, Dengjel, Jörn, Meisinger, Chris, Sigrist, Stephan J, Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844953/
https://www.ncbi.nlm.nih.gov/pubmed/24129513
http://dx.doi.org/10.1038/emboj.2013.228

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