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Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses
The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The expression of IFNλ4 is correlated with both poor spontaneous clearance of hepatitis C virus (HCV) and poor response to tre...
Autores principales: | Hamming, Ole J, Terczyńska-Dyla, Ewa, Vieyres, Gabrielle, Dijkman, Ronald, Jørgensen, Sanne E, Akhtar, Hashaam, Siupka, Piotr, Pietschmann, Thomas, Thiel, Volker, Hartmann, Rune |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Molecular Biology Organization
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844954/ https://www.ncbi.nlm.nih.gov/pubmed/24169568 http://dx.doi.org/10.1038/emboj.2013.232 |
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