MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?

Graft-versus-host disease (GVHD) is still the major complication of allogeneic hematopoietic stem cell transplantation. Despite extensive studies in understanding the pathophysiology of GVHD, its pathogenesis remains unclear. Recently, important functions of microRNAs have been demonstrated in vario...

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Detalles Bibliográficos
Autores principales: Atarod, Sadaf, Dickinson, Anne Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845018/
https://www.ncbi.nlm.nih.gov/pubmed/24348483
http://dx.doi.org/10.3389/fimmu.2013.00420
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author Atarod, Sadaf
Dickinson, Anne Mary
author_facet Atarod, Sadaf
Dickinson, Anne Mary
author_sort Atarod, Sadaf
collection PubMed
description Graft-versus-host disease (GVHD) is still the major complication of allogeneic hematopoietic stem cell transplantation. Despite extensive studies in understanding the pathophysiology of GVHD, its pathogenesis remains unclear. Recently, important functions of microRNAs have been demonstrated in various autoimmune diseases and cancers such as psoriasis and lymphoma. This review highlights the need to investigate the role of microRNAs in GVHD and hypothesizes that microRNAs may be one of the missing links in our understanding of GVHD, with the potential for novel therapeutics.
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spelling pubmed-38450182013-12-13 MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease? Atarod, Sadaf Dickinson, Anne Mary Front Immunol Immunology Graft-versus-host disease (GVHD) is still the major complication of allogeneic hematopoietic stem cell transplantation. Despite extensive studies in understanding the pathophysiology of GVHD, its pathogenesis remains unclear. Recently, important functions of microRNAs have been demonstrated in various autoimmune diseases and cancers such as psoriasis and lymphoma. This review highlights the need to investigate the role of microRNAs in GVHD and hypothesizes that microRNAs may be one of the missing links in our understanding of GVHD, with the potential for novel therapeutics. Frontiers Media S.A. 2013-12-02 /pmc/articles/PMC3845018/ /pubmed/24348483 http://dx.doi.org/10.3389/fimmu.2013.00420 Text en Copyright © 2013 Atarod and Dickinson. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Atarod, Sadaf
Dickinson, Anne Mary
MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?
title MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?
title_full MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?
title_fullStr MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?
title_full_unstemmed MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?
title_short MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?
title_sort micrornas: the missing link in the biology of graft-versus-host disease?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845018/
https://www.ncbi.nlm.nih.gov/pubmed/24348483
http://dx.doi.org/10.3389/fimmu.2013.00420
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