Selection on hemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses

The emergence of human-transmissible H5N1 avian influenza viruses poses a major pandemic threat. H5N1 viruses are thought to be highly genetically diverse both among and within hosts, but the effects of this diversity on viral replication and transmission are poorly understood. Here we use deep sequ...

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Detalles Bibliográficos
Autores principales: Wilker, Peter R., Dinis, Jorge M., Starrett, Gabriel, Imai, Masaki, Hatta, Masato, Nelson, Chase W., O’Connor, David H., Hughes, Austin L., Neumann, Gabriele, Kawaoka, Yoshihiro, Friedrich, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845350/
https://www.ncbi.nlm.nih.gov/pubmed/24149915
http://dx.doi.org/10.1038/ncomms3636

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