Notch Signaling and T-Helper Cells in EAE/MS

The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in embryogenesis, tissue homeostasis, angiogenesis, a...

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Detalles Bibliográficos
Autores principales: Bassil, Ribal, Orent, William, Elyaman, Wassim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845449/
https://www.ncbi.nlm.nih.gov/pubmed/24324509
http://dx.doi.org/10.1155/2013/570731
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author Bassil, Ribal
Orent, William
Elyaman, Wassim
author_facet Bassil, Ribal
Orent, William
Elyaman, Wassim
author_sort Bassil, Ribal
collection PubMed
description The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in embryogenesis, tissue homeostasis, angiogenesis, and immunoregulation. Multiple sclerosis (MS) is an incurable yet treatable autoimmune chronic inflammatory disease of the central nervous system. The aim of this review is to provide a brief description of the Notch signaling pathway, and summarize the current literature implicating Notch in the pathogenesis of MS.
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spelling pubmed-38454492013-12-09 Notch Signaling and T-Helper Cells in EAE/MS Bassil, Ribal Orent, William Elyaman, Wassim Clin Dev Immunol Review Article The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in embryogenesis, tissue homeostasis, angiogenesis, and immunoregulation. Multiple sclerosis (MS) is an incurable yet treatable autoimmune chronic inflammatory disease of the central nervous system. The aim of this review is to provide a brief description of the Notch signaling pathway, and summarize the current literature implicating Notch in the pathogenesis of MS. Hindawi Publishing Corporation 2013 2013-11-14 /pmc/articles/PMC3845449/ /pubmed/24324509 http://dx.doi.org/10.1155/2013/570731 Text en Copyright © 2013 Ribal Bassil et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bassil, Ribal
Orent, William
Elyaman, Wassim
Notch Signaling and T-Helper Cells in EAE/MS
title Notch Signaling and T-Helper Cells in EAE/MS
title_full Notch Signaling and T-Helper Cells in EAE/MS
title_fullStr Notch Signaling and T-Helper Cells in EAE/MS
title_full_unstemmed Notch Signaling and T-Helper Cells in EAE/MS
title_short Notch Signaling and T-Helper Cells in EAE/MS
title_sort notch signaling and t-helper cells in eae/ms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845449/
https://www.ncbi.nlm.nih.gov/pubmed/24324509
http://dx.doi.org/10.1155/2013/570731
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