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Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses

New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in sever...

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Detalles Bibliográficos
Autores principales: Zeng, Jing, Harris, Timothy J., Lim, Michael, Drake, Charles G., Tran, Phuoc T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845488/
https://www.ncbi.nlm.nih.gov/pubmed/24324970
http://dx.doi.org/10.1155/2013/658126
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author Zeng, Jing
Harris, Timothy J.
Lim, Michael
Drake, Charles G.
Tran, Phuoc T.
author_facet Zeng, Jing
Harris, Timothy J.
Lim, Michael
Drake, Charles G.
Tran, Phuoc T.
author_sort Zeng, Jing
collection PubMed
description New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model systems. These studies demonstrate that radiation combined with immunotherapy can result in superior efficacy for local tumor control. More alluring is the emergence of data suggesting an equally profound systemic response also known as “abscopal” effects with the combination of radiation and certain immunotherapies. Studies addressing optimal radiation dose, fractionation, and modality to be used in combination with immunotherapy still require further exploration. However, recent anecdotal clinical reports combining stereotactic or hypofractionated radiation regimens with immunotherapy have resulted in dramatic sustained clinical responses, both local and abscopal. Technologic advances in clinical radiation therapy has made it possible to deliver hypofractionated regimens anywhere in the body using stereotactic radiation techniques, facilitating further clinical investigations. Thus, stereotactic radiation in combination with immunotherapy agents represents an exciting and potentially fruitful new space for improving cancer therapeutic responses.
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spelling pubmed-38454882013-12-09 Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses Zeng, Jing Harris, Timothy J. Lim, Michael Drake, Charles G. Tran, Phuoc T. Biomed Res Int Review Article New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model systems. These studies demonstrate that radiation combined with immunotherapy can result in superior efficacy for local tumor control. More alluring is the emergence of data suggesting an equally profound systemic response also known as “abscopal” effects with the combination of radiation and certain immunotherapies. Studies addressing optimal radiation dose, fractionation, and modality to be used in combination with immunotherapy still require further exploration. However, recent anecdotal clinical reports combining stereotactic or hypofractionated radiation regimens with immunotherapy have resulted in dramatic sustained clinical responses, both local and abscopal. Technologic advances in clinical radiation therapy has made it possible to deliver hypofractionated regimens anywhere in the body using stereotactic radiation techniques, facilitating further clinical investigations. Thus, stereotactic radiation in combination with immunotherapy agents represents an exciting and potentially fruitful new space for improving cancer therapeutic responses. Hindawi Publishing Corporation 2013 2013-11-14 /pmc/articles/PMC3845488/ /pubmed/24324970 http://dx.doi.org/10.1155/2013/658126 Text en Copyright © 2013 Jing Zeng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zeng, Jing
Harris, Timothy J.
Lim, Michael
Drake, Charles G.
Tran, Phuoc T.
Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
title Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
title_full Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
title_fullStr Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
title_full_unstemmed Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
title_short Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
title_sort immune modulation and stereotactic radiation: improving local and abscopal responses
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845488/
https://www.ncbi.nlm.nih.gov/pubmed/24324970
http://dx.doi.org/10.1155/2013/658126
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