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Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis
Systemic chemotherapy is the basic palliative treatment for metastatic nasopharyngeal carcinoma (NPC); however, it is not known whether locoregional radiotherapy targeting the primary tumor and regional lymph nodes affects the survival of patients with metastatic NPC. Therefore, we aimed to retrospe...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sun Yat-sen University Cancer Center
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845550/ https://www.ncbi.nlm.nih.gov/pubmed/24206918 http://dx.doi.org/10.5732/cjc.013.10148 |
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author | Chen, Ming-Yuan Jiang, Rou Guo, Ling Zou, Xiong Liu, Qing Sun, Rui Qiu, Fang Xia, Zhong-Jun Huang, Hui-Qiang Zhang, Li Hong, Ming-Huang Mai, Hai-Qiang Qian, Chao-Nan |
author_facet | Chen, Ming-Yuan Jiang, Rou Guo, Ling Zou, Xiong Liu, Qing Sun, Rui Qiu, Fang Xia, Zhong-Jun Huang, Hui-Qiang Zhang, Li Hong, Ming-Huang Mai, Hai-Qiang Qian, Chao-Nan |
author_sort | Chen, Ming-Yuan |
collection | PubMed |
description | Systemic chemotherapy is the basic palliative treatment for metastatic nasopharyngeal carcinoma (NPC); however, it is not known whether locoregional radiotherapy targeting the primary tumor and regional lymph nodes affects the survival of patients with metastatic NPC. Therefore, we aimed to retrospectively evaluate the benefits of locoregional radiotherapy. A total of 408 patients with metastatic NPC were included in this study. The mortality risks of the patients undergoing supportive treatment and those undergoing chemotherapy were compared with that of patients undergoing locoregional radiotherapy delivered alone or in combination with chemotherapy. Univariate and multivariate analyses were conducted. The contributions of independent factors were assessed after adjustment for covariates with significant prognostic associations (P < 0.05). Both locoregional radiotherapy and systemic chemotherapy were identified as significant independent prognostic factors of overall survival (OS). The mortality risk was similar in the group undergoing locoregional radiotherapy alone and the group undergoing systemic chemotherapy alone [multi-adjusted hazard ratio (HR) = 0.9, P = 0.529]; this risk was 60% lower than that of the group undergoing supportive treatment (HR = 0.4, P = 0.004) and 130% higher than that of the group undergoing both systemic chemotherapy and locoregional radiotherapy (HR = 2.3, P < 0.001). In conclusion, locoregional radiotherapy, particularly when combined with systemic chemotherapy, is associated with improved survival of patients with metastatic NPC. |
format | Online Article Text |
id | pubmed-3845550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-38455502013-12-11 Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis Chen, Ming-Yuan Jiang, Rou Guo, Ling Zou, Xiong Liu, Qing Sun, Rui Qiu, Fang Xia, Zhong-Jun Huang, Hui-Qiang Zhang, Li Hong, Ming-Huang Mai, Hai-Qiang Qian, Chao-Nan Chin J Cancer Original Article Systemic chemotherapy is the basic palliative treatment for metastatic nasopharyngeal carcinoma (NPC); however, it is not known whether locoregional radiotherapy targeting the primary tumor and regional lymph nodes affects the survival of patients with metastatic NPC. Therefore, we aimed to retrospectively evaluate the benefits of locoregional radiotherapy. A total of 408 patients with metastatic NPC were included in this study. The mortality risks of the patients undergoing supportive treatment and those undergoing chemotherapy were compared with that of patients undergoing locoregional radiotherapy delivered alone or in combination with chemotherapy. Univariate and multivariate analyses were conducted. The contributions of independent factors were assessed after adjustment for covariates with significant prognostic associations (P < 0.05). Both locoregional radiotherapy and systemic chemotherapy were identified as significant independent prognostic factors of overall survival (OS). The mortality risk was similar in the group undergoing locoregional radiotherapy alone and the group undergoing systemic chemotherapy alone [multi-adjusted hazard ratio (HR) = 0.9, P = 0.529]; this risk was 60% lower than that of the group undergoing supportive treatment (HR = 0.4, P = 0.004) and 130% higher than that of the group undergoing both systemic chemotherapy and locoregional radiotherapy (HR = 2.3, P < 0.001). In conclusion, locoregional radiotherapy, particularly when combined with systemic chemotherapy, is associated with improved survival of patients with metastatic NPC. Sun Yat-sen University Cancer Center 2013-11 /pmc/articles/PMC3845550/ /pubmed/24206918 http://dx.doi.org/10.5732/cjc.013.10148 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Original Article Chen, Ming-Yuan Jiang, Rou Guo, Ling Zou, Xiong Liu, Qing Sun, Rui Qiu, Fang Xia, Zhong-Jun Huang, Hui-Qiang Zhang, Li Hong, Ming-Huang Mai, Hai-Qiang Qian, Chao-Nan Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
title | Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
title_full | Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
title_fullStr | Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
title_full_unstemmed | Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
title_short | Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
title_sort | locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845550/ https://www.ncbi.nlm.nih.gov/pubmed/24206918 http://dx.doi.org/10.5732/cjc.013.10148 |
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