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Clinical implications of microRNAs in liver cancer stem cells

The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor a...

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Detalles Bibliográficos
Autores principales: Chai, Stella, Ma, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845583/
https://www.ncbi.nlm.nih.gov/pubmed/23668930
http://dx.doi.org/10.5732/cjc.013.10038
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author Chai, Stella
Ma, Stephanie
author_facet Chai, Stella
Ma, Stephanie
author_sort Chai, Stella
collection PubMed
description The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver CSCs and highlights the need for further investigations of the role of miRNAs in regulating liver CSC subsets for possible future clinical applications.
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spelling pubmed-38455832013-12-11 Clinical implications of microRNAs in liver cancer stem cells Chai, Stella Ma, Stephanie Chin J Cancer Perspective The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver CSCs and highlights the need for further investigations of the role of miRNAs in regulating liver CSC subsets for possible future clinical applications. Sun Yat-sen University Cancer Center 2013-08 /pmc/articles/PMC3845583/ /pubmed/23668930 http://dx.doi.org/10.5732/cjc.013.10038 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Perspective
Chai, Stella
Ma, Stephanie
Clinical implications of microRNAs in liver cancer stem cells
title Clinical implications of microRNAs in liver cancer stem cells
title_full Clinical implications of microRNAs in liver cancer stem cells
title_fullStr Clinical implications of microRNAs in liver cancer stem cells
title_full_unstemmed Clinical implications of microRNAs in liver cancer stem cells
title_short Clinical implications of microRNAs in liver cancer stem cells
title_sort clinical implications of micrornas in liver cancer stem cells
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845583/
https://www.ncbi.nlm.nih.gov/pubmed/23668930
http://dx.doi.org/10.5732/cjc.013.10038
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