Epigenetic changes in colorectal cancer

Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting (LOI) is associated with colorectal neo...

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Detalles Bibliográficos
Autores principales: Jia, Yan, Guo, Mingzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845587/
https://www.ncbi.nlm.nih.gov/pubmed/22059907
http://dx.doi.org/10.5732/cjc.011.10245
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author Jia, Yan
Guo, Mingzhou
author_facet Jia, Yan
Guo, Mingzhou
author_sort Jia, Yan
collection PubMed
description Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting (LOI) is associated with colorectal neoplasia. Folate deficiency may cause colorectal Carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation. HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment. Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer. This review is mainly focused on DNA methylation, histone modification, and microRNA changes in colorectal cancer.
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spelling pubmed-38455872013-12-11 Epigenetic changes in colorectal cancer Jia, Yan Guo, Mingzhou Chin J Cancer Review Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting (LOI) is associated with colorectal neoplasia. Folate deficiency may cause colorectal Carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation. HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment. Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer. This review is mainly focused on DNA methylation, histone modification, and microRNA changes in colorectal cancer. Sun Yat-sen University Cancer Center 2013-01 /pmc/articles/PMC3845587/ /pubmed/22059907 http://dx.doi.org/10.5732/cjc.011.10245 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Jia, Yan
Guo, Mingzhou
Epigenetic changes in colorectal cancer
title Epigenetic changes in colorectal cancer
title_full Epigenetic changes in colorectal cancer
title_fullStr Epigenetic changes in colorectal cancer
title_full_unstemmed Epigenetic changes in colorectal cancer
title_short Epigenetic changes in colorectal cancer
title_sort epigenetic changes in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845587/
https://www.ncbi.nlm.nih.gov/pubmed/22059907
http://dx.doi.org/10.5732/cjc.011.10245
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