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Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma

Serum levels of soluble MHC class I-related chain A (sMICA) are related with the prognosis of various types of cancer; however, few studies on the prognostic value of sMICA in hepatocellular carcinoma (HCC) have been reported. In this study, we retrospectively investigated the relationship between s...

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Autores principales: Li, Jian-Jun, Pan, Ke, Gu, Mo-Fa, Chen, Min-Shan, Zhao, Jing-Jing, Wang, Hui, Liang, Xiao-Ting, Sun, Jian-Cong, Xia, Jian-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845598/
https://www.ncbi.nlm.nih.gov/pubmed/22704489
http://dx.doi.org/10.5732/cjc.012.10025
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author Li, Jian-Jun
Pan, Ke
Gu, Mo-Fa
Chen, Min-Shan
Zhao, Jing-Jing
Wang, Hui
Liang, Xiao-Ting
Sun, Jian-Cong
Xia, Jian-Chuan
author_facet Li, Jian-Jun
Pan, Ke
Gu, Mo-Fa
Chen, Min-Shan
Zhao, Jing-Jing
Wang, Hui
Liang, Xiao-Ting
Sun, Jian-Cong
Xia, Jian-Chuan
author_sort Li, Jian-Jun
collection PubMed
description Serum levels of soluble MHC class I-related chain A (sMICA) are related with the prognosis of various types of cancer; however, few studies on the prognostic value of sMICA in hepatocellular carcinoma (HCC) have been reported. In this study, we retrospectively investigated the relationship between sMICA levels and clinical features of advanced HCC, and we assessed the prognostic value of sMICA in advanced HCC. Furthermore, the relationship of serum sMICA levels and natural killer group 2, member D (NKG2D) expression on natural killer (NK) cells was also evaluated. We detected sMICA levels in the serum of 60 advanced HCC patients using enzyme-linked immunosorbent assay (ELISA) and measured expression levels of NKG2D on NK cells using flow Cytometry. We found that serum sMICA levels in HCC patients were in the range of 0.10–6.21 ng/mL. Chi-square analyses showed that sMICA level was significantly related with only tumor size. Survival analysis showed that a high sMICA level was significantly related with poor prognosis among HCC patients. Multivariate analyses indicated that sMICA was an independent prognostic factor. In addition, the levels of CD56(+)NKG2D(+) NK cells were within the range of 11.2%–55.4%, and correlation analyses indicated that sMICA level was negatively correlated with the level of NKG2D(+) NK cells. Our results suggest that serum sMICA levels may be an independent prognostic factor for advanced HCC.
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spelling pubmed-38455982013-12-11 Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma Li, Jian-Jun Pan, Ke Gu, Mo-Fa Chen, Min-Shan Zhao, Jing-Jing Wang, Hui Liang, Xiao-Ting Sun, Jian-Cong Xia, Jian-Chuan Chin J Cancer Original Article Serum levels of soluble MHC class I-related chain A (sMICA) are related with the prognosis of various types of cancer; however, few studies on the prognostic value of sMICA in hepatocellular carcinoma (HCC) have been reported. In this study, we retrospectively investigated the relationship between sMICA levels and clinical features of advanced HCC, and we assessed the prognostic value of sMICA in advanced HCC. Furthermore, the relationship of serum sMICA levels and natural killer group 2, member D (NKG2D) expression on natural killer (NK) cells was also evaluated. We detected sMICA levels in the serum of 60 advanced HCC patients using enzyme-linked immunosorbent assay (ELISA) and measured expression levels of NKG2D on NK cells using flow Cytometry. We found that serum sMICA levels in HCC patients were in the range of 0.10–6.21 ng/mL. Chi-square analyses showed that sMICA level was significantly related with only tumor size. Survival analysis showed that a high sMICA level was significantly related with poor prognosis among HCC patients. Multivariate analyses indicated that sMICA was an independent prognostic factor. In addition, the levels of CD56(+)NKG2D(+) NK cells were within the range of 11.2%–55.4%, and correlation analyses indicated that sMICA level was negatively correlated with the level of NKG2D(+) NK cells. Our results suggest that serum sMICA levels may be an independent prognostic factor for advanced HCC. Sun Yat-sen University Cancer Center 2013-03 /pmc/articles/PMC3845598/ /pubmed/22704489 http://dx.doi.org/10.5732/cjc.012.10025 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Original Article
Li, Jian-Jun
Pan, Ke
Gu, Mo-Fa
Chen, Min-Shan
Zhao, Jing-Jing
Wang, Hui
Liang, Xiao-Ting
Sun, Jian-Cong
Xia, Jian-Chuan
Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma
title Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma
title_full Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma
title_fullStr Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma
title_full_unstemmed Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma
title_short Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma
title_sort prognostic value of soluble mica levels in the serum of patients with advanced hepatocellular carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845598/
https://www.ncbi.nlm.nih.gov/pubmed/22704489
http://dx.doi.org/10.5732/cjc.012.10025
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