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The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China

V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archive...

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Autores principales: Zhou, Qi-Ming, Li, Wei, Guan, Yuan-Xiang, Zhang, Xing, Chen, Xin-Chun, Ding, Ya, Wen, Xi-Zhi, Peng, Rui-Qing, Yan, Shu-Mei, Zhang, Xiao-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845607/
https://www.ncbi.nlm.nih.gov/pubmed/23237222
http://dx.doi.org/10.5732/cjc.012.10121
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author Zhou, Qi-Ming
Li, Wei
Guan, Yuan-Xiang
Zhang, Xing
Chen, Xin-Chun
Ding, Ya
Wen, Xi-Zhi
Peng, Rui-Qing
Yan, Shu-Mei
Zhang, Xiao-Shi
author_facet Zhou, Qi-Ming
Li, Wei
Guan, Yuan-Xiang
Zhang, Xing
Chen, Xin-Chun
Ding, Ya
Wen, Xi-Zhi
Peng, Rui-Qing
Yan, Shu-Mei
Zhang, Xiao-Shi
author_sort Zhou, Qi-Ming
collection PubMed
description V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
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spelling pubmed-38456072013-12-11 The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China Zhou, Qi-Ming Li, Wei Guan, Yuan-Xiang Zhang, Xing Chen, Xin-Chun Ding, Ya Wen, Xi-Zhi Peng, Rui-Qing Yan, Shu-Mei Zhang, Xiao-Shi Chin J Cancer Brief Report V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy. Sun Yat-sen University Cancer Center 2013-07 /pmc/articles/PMC3845607/ /pubmed/23237222 http://dx.doi.org/10.5732/cjc.012.10121 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Brief Report
Zhou, Qi-Ming
Li, Wei
Guan, Yuan-Xiang
Zhang, Xing
Chen, Xin-Chun
Ding, Ya
Wen, Xi-Zhi
Peng, Rui-Qing
Yan, Shu-Mei
Zhang, Xiao-Shi
The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China
title The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China
title_full The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China
title_fullStr The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China
title_full_unstemmed The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China
title_short The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China
title_sort absence of the erbb4 hotspot mutations in melanomas in patients from southern china
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845607/
https://www.ncbi.nlm.nih.gov/pubmed/23237222
http://dx.doi.org/10.5732/cjc.012.10121
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