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Molecular markers as therapeutic targets in lung cancer
Lung cancer is responsible for 29% of cancer deaths in the United States and has very low 5-year survival rates of approximately 11% in men and 15% in women. Although the early diagnosis of lung cancer may increase the survival rate with adequate treatment, advanced lung cancers are often metastasiz...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sun Yat-sen University Cancer Center
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845617/ https://www.ncbi.nlm.nih.gov/pubmed/23369726 http://dx.doi.org/10.5732/cjc.013.10011 |
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author | Tseng, Hsin-Hui He, Biao |
author_facet | Tseng, Hsin-Hui He, Biao |
author_sort | Tseng, Hsin-Hui |
collection | PubMed |
description | Lung cancer is responsible for 29% of cancer deaths in the United States and has very low 5-year survival rates of approximately 11% in men and 15% in women. Although the early diagnosis of lung cancer may increase the survival rate with adequate treatment, advanced lung cancers are often metastasized and receive limited benefit from therapeutic regimens. As conventional treatments for lung cancer reach their limitations, researchers have attempted to discover novel drug therapies aimed at specific targets contributing to the progression of tumorigenesis. Recent advances in systems biology have enabled the molecular biology of lung Carcinogenesis to be elucidated. Our understanding of the physiologic processes of tumor development provide a means to design more effective and specific drugs with less toxicity, thereby accelerating the delivery of new drug therapies to the patient's bedside. |
format | Online Article Text |
id | pubmed-3845617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-38456172013-12-11 Molecular markers as therapeutic targets in lung cancer Tseng, Hsin-Hui He, Biao Chin J Cancer Editorial Lung cancer is responsible for 29% of cancer deaths in the United States and has very low 5-year survival rates of approximately 11% in men and 15% in women. Although the early diagnosis of lung cancer may increase the survival rate with adequate treatment, advanced lung cancers are often metastasized and receive limited benefit from therapeutic regimens. As conventional treatments for lung cancer reach their limitations, researchers have attempted to discover novel drug therapies aimed at specific targets contributing to the progression of tumorigenesis. Recent advances in systems biology have enabled the molecular biology of lung Carcinogenesis to be elucidated. Our understanding of the physiologic processes of tumor development provide a means to design more effective and specific drugs with less toxicity, thereby accelerating the delivery of new drug therapies to the patient's bedside. Sun Yat-sen University Cancer Center 2013-02 /pmc/articles/PMC3845617/ /pubmed/23369726 http://dx.doi.org/10.5732/cjc.013.10011 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Editorial Tseng, Hsin-Hui He, Biao Molecular markers as therapeutic targets in lung cancer |
title | Molecular markers as therapeutic targets in lung cancer |
title_full | Molecular markers as therapeutic targets in lung cancer |
title_fullStr | Molecular markers as therapeutic targets in lung cancer |
title_full_unstemmed | Molecular markers as therapeutic targets in lung cancer |
title_short | Molecular markers as therapeutic targets in lung cancer |
title_sort | molecular markers as therapeutic targets in lung cancer |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845617/ https://www.ncbi.nlm.nih.gov/pubmed/23369726 http://dx.doi.org/10.5732/cjc.013.10011 |
work_keys_str_mv | AT tsenghsinhui molecularmarkersastherapeutictargetsinlungcancer AT hebiao molecularmarkersastherapeutictargetsinlungcancer |