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Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review

Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other tha...

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Autores principales: Mohd-Radzman, Nabilatul Hani, Ismail, W. I. W., Adam, Zainah, Jaapar, Siti Safura, Adam, Aishah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845826/
https://www.ncbi.nlm.nih.gov/pubmed/24324517
http://dx.doi.org/10.1155/2013/718049
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author Mohd-Radzman, Nabilatul Hani
Ismail, W. I. W.
Adam, Zainah
Jaapar, Siti Safura
Adam, Aishah
author_facet Mohd-Radzman, Nabilatul Hani
Ismail, W. I. W.
Adam, Zainah
Jaapar, Siti Safura
Adam, Aishah
author_sort Mohd-Radzman, Nabilatul Hani
collection PubMed
description Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes. Hence, studying insulin resistance is of particular importance in unravelling the pathways employed by such diseases. In this review, mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, will be discussed. Suggested mechanisms for actions in normal and disrupted states were also visualised in several manually constructed diagrams to capture an overall view of the insulin-signalling pathway and its related components. The underlying constituents of medicinal significance found in the Stevia rebaudiana Bertoni plant (among other plants that potentiate antihyperglycemic activities) were explored in further depth. Understanding these factors and their mechanisms may be essential for comprehending the progression of insulin resistance towards the development of diabetes mellitus.
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spelling pubmed-38458262013-12-09 Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review Mohd-Radzman, Nabilatul Hani Ismail, W. I. W. Adam, Zainah Jaapar, Siti Safura Adam, Aishah Evid Based Complement Alternat Med Review Article Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes. Hence, studying insulin resistance is of particular importance in unravelling the pathways employed by such diseases. In this review, mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, will be discussed. Suggested mechanisms for actions in normal and disrupted states were also visualised in several manually constructed diagrams to capture an overall view of the insulin-signalling pathway and its related components. The underlying constituents of medicinal significance found in the Stevia rebaudiana Bertoni plant (among other plants that potentiate antihyperglycemic activities) were explored in further depth. Understanding these factors and their mechanisms may be essential for comprehending the progression of insulin resistance towards the development of diabetes mellitus. Hindawi Publishing Corporation 2013 2013-11-12 /pmc/articles/PMC3845826/ /pubmed/24324517 http://dx.doi.org/10.1155/2013/718049 Text en Copyright © 2013 Nabilatul Hani Mohd-Radzman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mohd-Radzman, Nabilatul Hani
Ismail, W. I. W.
Adam, Zainah
Jaapar, Siti Safura
Adam, Aishah
Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
title Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
title_full Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
title_fullStr Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
title_full_unstemmed Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
title_short Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
title_sort potential roles of stevia rebaudiana bertoni in abrogating insulin resistance and diabetes: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845826/
https://www.ncbi.nlm.nih.gov/pubmed/24324517
http://dx.doi.org/10.1155/2013/718049
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