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Activation of the central nervous system induced by micro-magnetic stimulation
Electrical and transcranial magnetic stimulation have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for investigating nervous system functions. Despite this success, these technologi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845906/ https://www.ncbi.nlm.nih.gov/pubmed/24030203 http://dx.doi.org/10.1038/ncomms3463 |
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author | Park, Hyun-Joo Bonmassar, Giorgio Kaltenbach, James A. Machado, Andre G. Manzoor, Nauman F. Gale, John T. |
author_facet | Park, Hyun-Joo Bonmassar, Giorgio Kaltenbach, James A. Machado, Andre G. Manzoor, Nauman F. Gale, John T. |
author_sort | Park, Hyun-Joo |
collection | PubMed |
description | Electrical and transcranial magnetic stimulation have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for investigating nervous system functions. Despite this success, these technologies have technical and practical limitations impeding the maximization of their full clinical and preclinical potential. Recently, micro-magnetic stimulation, which may offer advantages over electrical and transcranial magnetic stimulation, has proven effective in activating the neuronal circuitry of the retina in vitro. Here we demonstrate that this technology is also capable of activating neuronal circuitry on a systems level using an in vivo preparation. Specifically, the application of micro-magnetic fields to the dorsal cochlear nucleus activates inferior colliculus neurons. Additionally, we demonstrate the efficacy and characteristics of activation using different magnetic stimulation parameters. These findings provide a rationale for further exploration of micro-magnetic stimulation as a prospective tool for clinical and preclinical applications. |
format | Online Article Text |
id | pubmed-3845906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-38459062014-03-13 Activation of the central nervous system induced by micro-magnetic stimulation Park, Hyun-Joo Bonmassar, Giorgio Kaltenbach, James A. Machado, Andre G. Manzoor, Nauman F. Gale, John T. Nat Commun Article Electrical and transcranial magnetic stimulation have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for investigating nervous system functions. Despite this success, these technologies have technical and practical limitations impeding the maximization of their full clinical and preclinical potential. Recently, micro-magnetic stimulation, which may offer advantages over electrical and transcranial magnetic stimulation, has proven effective in activating the neuronal circuitry of the retina in vitro. Here we demonstrate that this technology is also capable of activating neuronal circuitry on a systems level using an in vivo preparation. Specifically, the application of micro-magnetic fields to the dorsal cochlear nucleus activates inferior colliculus neurons. Additionally, we demonstrate the efficacy and characteristics of activation using different magnetic stimulation parameters. These findings provide a rationale for further exploration of micro-magnetic stimulation as a prospective tool for clinical and preclinical applications. 2013 /pmc/articles/PMC3845906/ /pubmed/24030203 http://dx.doi.org/10.1038/ncomms3463 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Park, Hyun-Joo Bonmassar, Giorgio Kaltenbach, James A. Machado, Andre G. Manzoor, Nauman F. Gale, John T. Activation of the central nervous system induced by micro-magnetic stimulation |
title | Activation of the central nervous system induced by micro-magnetic stimulation |
title_full | Activation of the central nervous system induced by micro-magnetic stimulation |
title_fullStr | Activation of the central nervous system induced by micro-magnetic stimulation |
title_full_unstemmed | Activation of the central nervous system induced by micro-magnetic stimulation |
title_short | Activation of the central nervous system induced by micro-magnetic stimulation |
title_sort | activation of the central nervous system induced by micro-magnetic stimulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845906/ https://www.ncbi.nlm.nih.gov/pubmed/24030203 http://dx.doi.org/10.1038/ncomms3463 |
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