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To use or not to use: an update on licit and illicit ketamine use
Ketamine, a derivative of phencyclidine that was developed in the 1960s, is an anesthetic and analgesic with hallucinogenic effects. In this paper, the pharmacological and toxicological effects of ketamine are briefly reviewed. Ketamine possesses a wide safety margin but such a therapeutic benefit i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846302/ https://www.ncbi.nlm.nih.gov/pubmed/24474851 http://dx.doi.org/10.2147/SAR.S15458 |
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author | Li, Jih-Heng Vicknasingam, Balasingam Cheung, Yuet-Wah Zhou, Wang Nurhidayat, Adhi Wibowo Jarlais, Don C Des Schottenfeld, Richard |
author_facet | Li, Jih-Heng Vicknasingam, Balasingam Cheung, Yuet-Wah Zhou, Wang Nurhidayat, Adhi Wibowo Jarlais, Don C Des Schottenfeld, Richard |
author_sort | Li, Jih-Heng |
collection | PubMed |
description | Ketamine, a derivative of phencyclidine that was developed in the 1960s, is an anesthetic and analgesic with hallucinogenic effects. In this paper, the pharmacological and toxicological effects of ketamine are briefly reviewed. Ketamine possesses a wide safety margin but such a therapeutic benefit is somewhat offset by its emergence phenomenon (mind-body dissociation and delirium) and hallucinogenic effects. The increasing abuse of ketamine, initially predominantly in recreational scenes to experience a “k-hole” and other hallucinatory effects but more recently also as a drug abused during the workday or at home, has further pushed governments to confine its usage in many countries. Recently, urinary tract dysfunction has been associated with long-term ketamine use. In some long-term ketamine users, such damage can be irreversible and could result in renal failure and dialysis. Although ketamine has not yet been scheduled in the United Nations Conventions, previous studies using different assessment parameters to score the overall harms of drugs indicated that ketamine may cause more harm than some of the United Nations scheduled drugs. Some countries in Southeast and East Asia have reported an escalating situation of ketamine abuse. Dependence, lower urinary tract dysfunction, and sexual impulse or violence were the most notable among the ketamine-associated symptoms in these countries. These results implied that the danger of ketamine may have been underestimated previously. Therefore, the severity levels of the ketamine-associated problems should be scrutinized more carefully and objectively. To prevent ketamine from being improperly used and evolving into an epidemic, a thorough survey on the prevalence and characteristics of illicit ketamine use is imperative so that suitable policy and measures can be taken. On the other hand, recent findings that ketamine could be useful for treating major depressive disorder has given this old drug a new impetus. If ketamine is indeed a remedy for treating depression, more research on the risks and benefits of its clinical use will be indispensable. |
format | Online Article Text |
id | pubmed-3846302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38463022014-01-28 To use or not to use: an update on licit and illicit ketamine use Li, Jih-Heng Vicknasingam, Balasingam Cheung, Yuet-Wah Zhou, Wang Nurhidayat, Adhi Wibowo Jarlais, Don C Des Schottenfeld, Richard Subst Abuse Rehabil Review Ketamine, a derivative of phencyclidine that was developed in the 1960s, is an anesthetic and analgesic with hallucinogenic effects. In this paper, the pharmacological and toxicological effects of ketamine are briefly reviewed. Ketamine possesses a wide safety margin but such a therapeutic benefit is somewhat offset by its emergence phenomenon (mind-body dissociation and delirium) and hallucinogenic effects. The increasing abuse of ketamine, initially predominantly in recreational scenes to experience a “k-hole” and other hallucinatory effects but more recently also as a drug abused during the workday or at home, has further pushed governments to confine its usage in many countries. Recently, urinary tract dysfunction has been associated with long-term ketamine use. In some long-term ketamine users, such damage can be irreversible and could result in renal failure and dialysis. Although ketamine has not yet been scheduled in the United Nations Conventions, previous studies using different assessment parameters to score the overall harms of drugs indicated that ketamine may cause more harm than some of the United Nations scheduled drugs. Some countries in Southeast and East Asia have reported an escalating situation of ketamine abuse. Dependence, lower urinary tract dysfunction, and sexual impulse or violence were the most notable among the ketamine-associated symptoms in these countries. These results implied that the danger of ketamine may have been underestimated previously. Therefore, the severity levels of the ketamine-associated problems should be scrutinized more carefully and objectively. To prevent ketamine from being improperly used and evolving into an epidemic, a thorough survey on the prevalence and characteristics of illicit ketamine use is imperative so that suitable policy and measures can be taken. On the other hand, recent findings that ketamine could be useful for treating major depressive disorder has given this old drug a new impetus. If ketamine is indeed a remedy for treating depression, more research on the risks and benefits of its clinical use will be indispensable. Dove Medical Press 2011-03-16 /pmc/articles/PMC3846302/ /pubmed/24474851 http://dx.doi.org/10.2147/SAR.S15458 Text en © 2011 Li et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Li, Jih-Heng Vicknasingam, Balasingam Cheung, Yuet-Wah Zhou, Wang Nurhidayat, Adhi Wibowo Jarlais, Don C Des Schottenfeld, Richard To use or not to use: an update on licit and illicit ketamine use |
title | To use or not to use: an update on licit and illicit ketamine use |
title_full | To use or not to use: an update on licit and illicit ketamine use |
title_fullStr | To use or not to use: an update on licit and illicit ketamine use |
title_full_unstemmed | To use or not to use: an update on licit and illicit ketamine use |
title_short | To use or not to use: an update on licit and illicit ketamine use |
title_sort | to use or not to use: an update on licit and illicit ketamine use |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846302/ https://www.ncbi.nlm.nih.gov/pubmed/24474851 http://dx.doi.org/10.2147/SAR.S15458 |
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