Liver stiffness: a novel parameter for the diagnosis of liver disease

The noninvasive quantitation of liver stiffness (LS) by ultrasound based transient elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely liver cirrhosis. Alternative techniques such as acoustic radiation impulse frequency imaging or magnetic resonance elastography...

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Autores principales: Mueller, Sebastian, Sandrin, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846375/
https://www.ncbi.nlm.nih.gov/pubmed/24367208
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author Mueller, Sebastian
Sandrin, Laurent
author_facet Mueller, Sebastian
Sandrin, Laurent
author_sort Mueller, Sebastian
collection PubMed
description The noninvasive quantitation of liver stiffness (LS) by ultrasound based transient elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely liver cirrhosis. Alternative techniques such as acoustic radiation impulse frequency imaging or magnetic resonance elastography are currently under investigation. LS is an excellent surrogate marker of advanced fibrosis (F3) and cirrhosis (F4) outscoring all previous noninvasive approaches to detect cirrhosis. LS values below 6 kPa are considered as normal and exclude ongoing liver disease. LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. LS highly correlates with portal pressure, and esophageal varices are likely at values >20 kPa. Many other factors may also increase LS such as hepatic infiltration with tumor cells, mast cells (mastocytosis), inflammatory cells (all forms of hepatitis) or amyloidosis. In addition, LS is directly correlated with the venous pressure (eg, during liver congestion) and is increased during mechanic cholestasis. Thus, LS should always be interpreted in the context of clinical, imaging and laboratory findings. Finally, LS has helped to better understand the molecular mechanisms underlying liver fibrosis. The novel pressure-stiffness-fibrosis sequence hypothesis is introduced.
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spelling pubmed-38463752013-12-23 Liver stiffness: a novel parameter for the diagnosis of liver disease Mueller, Sebastian Sandrin, Laurent Hepat Med Review The noninvasive quantitation of liver stiffness (LS) by ultrasound based transient elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely liver cirrhosis. Alternative techniques such as acoustic radiation impulse frequency imaging or magnetic resonance elastography are currently under investigation. LS is an excellent surrogate marker of advanced fibrosis (F3) and cirrhosis (F4) outscoring all previous noninvasive approaches to detect cirrhosis. LS values below 6 kPa are considered as normal and exclude ongoing liver disease. LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. LS highly correlates with portal pressure, and esophageal varices are likely at values >20 kPa. Many other factors may also increase LS such as hepatic infiltration with tumor cells, mast cells (mastocytosis), inflammatory cells (all forms of hepatitis) or amyloidosis. In addition, LS is directly correlated with the venous pressure (eg, during liver congestion) and is increased during mechanic cholestasis. Thus, LS should always be interpreted in the context of clinical, imaging and laboratory findings. Finally, LS has helped to better understand the molecular mechanisms underlying liver fibrosis. The novel pressure-stiffness-fibrosis sequence hypothesis is introduced. Dove Medical Press 2010-05-25 /pmc/articles/PMC3846375/ /pubmed/24367208 Text en © 2010 Mueller and Sandrin, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Mueller, Sebastian
Sandrin, Laurent
Liver stiffness: a novel parameter for the diagnosis of liver disease
title Liver stiffness: a novel parameter for the diagnosis of liver disease
title_full Liver stiffness: a novel parameter for the diagnosis of liver disease
title_fullStr Liver stiffness: a novel parameter for the diagnosis of liver disease
title_full_unstemmed Liver stiffness: a novel parameter for the diagnosis of liver disease
title_short Liver stiffness: a novel parameter for the diagnosis of liver disease
title_sort liver stiffness: a novel parameter for the diagnosis of liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846375/
https://www.ncbi.nlm.nih.gov/pubmed/24367208
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