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Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)

BACKGROUND: Oxytocin has been reported for a wide range of adverse effects in different species of lactating animals. The present study was aimed to evaluate the adverse effects of oxytocin on biomarkers of oxidative stress in buffaloes. Lactating buffaloes (n = 40) were randomly selected from a com...

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Autores principales: Iqbal, Zafar, Rahman, Zia Ur, Muhammad, Faqir, Khaliq, Tanweer, Anwar, Haseeb, Awais, Mian Muhammad, Sadaf, Saima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846439/
https://www.ncbi.nlm.nih.gov/pubmed/23981231
http://dx.doi.org/10.1186/1746-6148-9-169
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author Iqbal, Zafar
Rahman, Zia Ur
Muhammad, Faqir
Khaliq, Tanweer
Anwar, Haseeb
Awais, Mian Muhammad
Sadaf, Saima
author_facet Iqbal, Zafar
Rahman, Zia Ur
Muhammad, Faqir
Khaliq, Tanweer
Anwar, Haseeb
Awais, Mian Muhammad
Sadaf, Saima
author_sort Iqbal, Zafar
collection PubMed
description BACKGROUND: Oxytocin has been reported for a wide range of adverse effects in different species of lactating animals. The present study was aimed to evaluate the adverse effects of oxytocin on biomarkers of oxidative stress in buffaloes. Lactating buffaloes (n = 40) were randomly selected from a commercial dairy farm located in the peri-urban area of district Faisalabad, Pakistan and divided into two equal groups viz. treatment and control groups, each containing 20 buffaloes. Buffaloes in treatment group were injected with oxytocin before each milking (morning and evening) for milk let down; whereas, animals in control group were milked naturally without oxytocin injection. Both the groups were assessed for oxidative stress biomarkers. RESULTS: Results showed significantly higher levels (P ≤ 0.05) of TOS, tHcy and ceruloplasmin oxidase activity in lactating buffaloes injected with oxytocin as compared to those of control group. On the other hand, serum levels of TAS, PON1 and arylesterase were significantly lower (P ≤ 0.05) in the buffaloes of treatment group. CONCLUSIONS: Oxytocin injection in lactating buffaloes resulted in elevated oxidative stress by increasing the total homocysteine and ceruloplasmin oxidase activity and decreasing enzymatic activities of antioxidant enzymes including paraoxonase-1 and arylesterase; that might render the animals to poor productive and reproductive potential.
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spelling pubmed-38464392013-12-06 Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi) Iqbal, Zafar Rahman, Zia Ur Muhammad, Faqir Khaliq, Tanweer Anwar, Haseeb Awais, Mian Muhammad Sadaf, Saima BMC Vet Res Research Article BACKGROUND: Oxytocin has been reported for a wide range of adverse effects in different species of lactating animals. The present study was aimed to evaluate the adverse effects of oxytocin on biomarkers of oxidative stress in buffaloes. Lactating buffaloes (n = 40) were randomly selected from a commercial dairy farm located in the peri-urban area of district Faisalabad, Pakistan and divided into two equal groups viz. treatment and control groups, each containing 20 buffaloes. Buffaloes in treatment group were injected with oxytocin before each milking (morning and evening) for milk let down; whereas, animals in control group were milked naturally without oxytocin injection. Both the groups were assessed for oxidative stress biomarkers. RESULTS: Results showed significantly higher levels (P ≤ 0.05) of TOS, tHcy and ceruloplasmin oxidase activity in lactating buffaloes injected with oxytocin as compared to those of control group. On the other hand, serum levels of TAS, PON1 and arylesterase were significantly lower (P ≤ 0.05) in the buffaloes of treatment group. CONCLUSIONS: Oxytocin injection in lactating buffaloes resulted in elevated oxidative stress by increasing the total homocysteine and ceruloplasmin oxidase activity and decreasing enzymatic activities of antioxidant enzymes including paraoxonase-1 and arylesterase; that might render the animals to poor productive and reproductive potential. BioMed Central 2013-08-27 /pmc/articles/PMC3846439/ /pubmed/23981231 http://dx.doi.org/10.1186/1746-6148-9-169 Text en Copyright © 2013 Iqbal et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Iqbal, Zafar
Rahman, Zia Ur
Muhammad, Faqir
Khaliq, Tanweer
Anwar, Haseeb
Awais, Mian Muhammad
Sadaf, Saima
Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)
title Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)
title_full Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)
title_fullStr Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)
title_full_unstemmed Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)
title_short Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)
title_sort oxytocin induced oxidative stress in lactating bubalis bubalis (nili ravi)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846439/
https://www.ncbi.nlm.nih.gov/pubmed/23981231
http://dx.doi.org/10.1186/1746-6148-9-169
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