Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors

BACKGROUND: NMDA receptors are ligand-gated ion channels with essential roles in glutamatergic synaptic transmission and plasticity in the CNS. As co-receptors for glutamate and glycine, gating of the NMDA receptor/channel pore requires agonist binding to the glycine sites, as well as to the glutama...

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Detalles Bibliográficos
Autores principales: Han, Lu, Campanucci, Verónica A, Cooke, James, Salter, Michael W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846451/
https://www.ncbi.nlm.nih.gov/pubmed/23941530
http://dx.doi.org/10.1186/1756-6606-6-36

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