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Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

BACKGROUND & AIMS: While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) c...

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Autores principales:	Hendrikx, Tim, Bieghs, Veerle, Walenbergh, Sofie M. A., van Gorp, Patrick J., Verheyen, Fons, Jeurissen, Mike L. J., Steinbusch, Mandy M. F., Vaes, Nathalie, Binder, Christoph J., Koek, Ger H., Stienstra, Rinke, Netea, Mihai G., Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846469/ https://www.ncbi.nlm.nih.gov/pubmed/24312444 http://dx.doi.org/10.1371/journal.pone.0078792

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