Active Inhibitor-1 Maintains Protein Hyper-Phosphorylation in Aging Hearts and Halts Remodeling in Failing Hearts

Impaired sarcoplasmic reticulum calcium cycling and depressed contractility are key characteristics in heart failure. Defects in sarcoplasmic reticulum function are characterized by decreased SERCA2a Ca-transport that is partially attributable to dephosphorylation of its regulator phospholamban by i...

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Detalles Bibliográficos
Autores principales: Pritchard, Tracy J., Kawase, Yoshiaki, Haghighi, Kobra, Anjak, Ahmad, Cai, Wenfeng, Jiang, Min, Nicolaou, Persoulla, Pylar, George, Karakikes, Ioannis, Rapti, Kleopatra, Rubinstein, Jack, Hajjar, Roger J., Kranias, Evangelia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846572/
https://www.ncbi.nlm.nih.gov/pubmed/24312496
http://dx.doi.org/10.1371/journal.pone.0080717

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