Cargando…

Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease

Detalles Bibliográficos
Autores principales:	Golde, Todd E, Felsenstein, Kevin, Chakrabarty, Paramita, Li, Andy, Moore, Brenda, In, Jung Joo, Cruz, Pedor, Price, Ashely, Borchelt, David, Janus, Christopher, Cebballos-Diaz, Carolina, Rosario, Awilda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Oral Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846712/ http://dx.doi.org/10.1186/1750-1326-8-S1-O36

Ejemplares similares

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice
por: Prasad, Tuhina, et al.
Publicado: (2017)

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
por: Chakrabarty, Paramita, et al.
Publicado: (2013)

Normal cognition in transgenic BRI2-Aβ mice
por: Kim, Jungsu, et al.
Publicado: (2013)

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
por: McFarland, Karen N, et al.
Publicado: (2021)

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator
por: Jung, Joo In, et al.
Publicado: (2015)

Astrocytic apoE4 and tau: Deadly combination for neurons
por: Chakrabarty, Paramita, et al.
Publicado: (2021)

Il-10 signaling reduces survival in mouse models of synucleinopathy
por: Cockey, Samuel G., et al.
Publicado: (2021)

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
por: Golde, Todd E, et al.
Publicado: (2013)

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
por: Das, Pritam, et al.
Publicado: (2012)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
por: Jung, Joo In, et al.
Publicado: (2014)

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease
por: Williams, Tosha, et al.
Publicado: (2020)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
por: Dhillon, Jess-Karan S., et al.
Publicado: (2017)

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
por: Ceballos-Diaz, Carolina, et al.
Publicado: (2015)

Microglia-specific targeting by novel capsid-modified AAV6 vectors
por: Rosario, Awilda M, et al.
Publicado: (2016)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis
por: Xu, Guilian, et al.
Publicado: (2020)

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
por: Chakrabarty, Paramita, et al.
Publicado: (2011)

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
por: Golde, Todd E
Publicado: (2009)

Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy
por: Das, Pritam, et al.
Publicado: (2006)

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
por: Chakrabarty, Paramita, et al.
Publicado: (2012)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Harnessing RNA interference to prevent or treat HSV-2 and HIV
por: Lieberman, Judy
Publicado: (2006)

Lysosomal function in neurodegenerative diseases
por: Zhang, Jianhua
Publicado: (2012)

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains
por: Moore, Brenda D, et al.
Publicado: (2012)

Harnessing host innate immunity may combat acquired resistance to BRAFi
por: Tan, Thomas, et al.
Publicado: (2014)

"What kills neurons in neurodegenerative diseases?", a review series in an open access journal
por: Golde, Todd E, et al.
Publicado: (2009)

Harnessing Endogenous Cellular Mechanisms for Bone Repair
por: Lo Sicco, Claudia, et al.
Publicado: (2017)

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics
por: Cook, Alexander B., et al.
Publicado: (2021)

The transcription factor XBP-1 in neurodegenerative diseases
por: Checler, Frédéric, et al.
Publicado: (2013)

Organotypic brain slice cultures to model neurodegenerative proteinopathies
por: Croft, C. L., et al.
Publicado: (2019)

Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
por: Machhi, Jatin, et al.
Publicado: (2020)

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases
por: Golde, Todd E, et al.
Publicado: (2009)

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
por: Smith, Ethan D., et al.
Publicado: (2023)

Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases
por: Moreno-García, Leticia, et al.
Publicado: (2020)

Immunity to human endogenous retroviruses
por: Nixon, Douglas F
Publicado: (2011)

IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
por: Strickland, Michael R., et al.
Publicado: (2020)

Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
por: Strickland, Michael R., et al.
Publicado: (2021)

Revealing cancer initiating cells in metastatic melanomas by harnessing the host′s anti tumor humoral immune mechanisms
por: Kotlan, Beatrix, et al.
Publicado: (2014)

Delivery of stem cells to the brain: potential for treatment of neurodegenerative disease
por: Burgess, Alison, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rr672f7i540hv0evkf5i23skpl