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Activated protein C resistance in Behcet’s disease

Behcet’s disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most frequent. Endothelial dysfunction resulting from vascular inflammation is considered to be an...

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Autores principales: Abdel Badaee, Hoda, Edrees, Amr, Amin, Sherif, El Amir, Maher, Ragab, Gaafar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846854/
https://www.ncbi.nlm.nih.gov/pubmed/24004911
http://dx.doi.org/10.1186/1477-9560-11-17
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author Abdel Badaee, Hoda
Edrees, Amr
Amin, Sherif
El Amir, Maher
Ragab, Gaafar
author_facet Abdel Badaee, Hoda
Edrees, Amr
Amin, Sherif
El Amir, Maher
Ragab, Gaafar
author_sort Abdel Badaee, Hoda
collection PubMed
description Behcet’s disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most frequent. Endothelial dysfunction resulting from vascular inflammation is considered to be an important factor of thrombosis, although the endothelial injury itself cannot completely explain the hypercoagulable state of the disease because other vasculitis syndromes do not increase the risk of thrombosis. The aim of this study is to evaluate the prevalence of activated protein C resistance (APC-R) in Egyptian patients with Behcet’s disease. Also, to detect hyperhomocysteinemia in selected cases (with vascular complications) to assess their relationship with thromboembolic complications. The APC resistance ratio mean in the group of patients with vascular involvement was 2.6 ± 0.8 which was less than the group with no vascular involvement 2.8 ± 0.6, with non- significant P-value (0.5). There was more incidence of ocular lesions in the group of patients with high homocysteine level than the group of patients with normal homocytsteine level with significant P-value (0.08).
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spelling pubmed-38468542013-12-04 Activated protein C resistance in Behcet’s disease Abdel Badaee, Hoda Edrees, Amr Amin, Sherif El Amir, Maher Ragab, Gaafar Thromb J Original Clinical Investigation Behcet’s disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most frequent. Endothelial dysfunction resulting from vascular inflammation is considered to be an important factor of thrombosis, although the endothelial injury itself cannot completely explain the hypercoagulable state of the disease because other vasculitis syndromes do not increase the risk of thrombosis. The aim of this study is to evaluate the prevalence of activated protein C resistance (APC-R) in Egyptian patients with Behcet’s disease. Also, to detect hyperhomocysteinemia in selected cases (with vascular complications) to assess their relationship with thromboembolic complications. The APC resistance ratio mean in the group of patients with vascular involvement was 2.6 ± 0.8 which was less than the group with no vascular involvement 2.8 ± 0.6, with non- significant P-value (0.5). There was more incidence of ocular lesions in the group of patients with high homocysteine level than the group of patients with normal homocytsteine level with significant P-value (0.08). BioMed Central 2013-09-02 /pmc/articles/PMC3846854/ /pubmed/24004911 http://dx.doi.org/10.1186/1477-9560-11-17 Text en Copyright © 2013 Abdel Badaee et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Clinical Investigation
Abdel Badaee, Hoda
Edrees, Amr
Amin, Sherif
El Amir, Maher
Ragab, Gaafar
Activated protein C resistance in Behcet’s disease
title Activated protein C resistance in Behcet’s disease
title_full Activated protein C resistance in Behcet’s disease
title_fullStr Activated protein C resistance in Behcet’s disease
title_full_unstemmed Activated protein C resistance in Behcet’s disease
title_short Activated protein C resistance in Behcet’s disease
title_sort activated protein c resistance in behcet’s disease
topic Original Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846854/
https://www.ncbi.nlm.nih.gov/pubmed/24004911
http://dx.doi.org/10.1186/1477-9560-11-17
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