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Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study

BACKGROUND: The purpose of the present study was to compare dynamic muscle strength, functional performance, fatigue, and quality of life in premenopausal systemic lupus erythematosus (SLE) patients with low disease activity versus matched-healthy controls and to determine the association of dynamic...

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Autores principales: Balsamo, Sandor, da Mota, Licia Maria Henrique, de Carvalho, Jozélio Freire, Nascimento, Dahan da Cunha, Tibana, Ramires Alsamir, Santos de Santana, Frederico, Moreno, Ricardo Lima, Gualano, Bruno, dos Santos-Neto, Leopoldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847135/
https://www.ncbi.nlm.nih.gov/pubmed/24011222
http://dx.doi.org/10.1186/1471-2474-14-263
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author Balsamo, Sandor
da Mota, Licia Maria Henrique
de Carvalho, Jozélio Freire
Nascimento, Dahan da Cunha
Tibana, Ramires Alsamir
Santos de Santana, Frederico
Moreno, Ricardo Lima
Gualano, Bruno
dos Santos-Neto, Leopoldo
author_facet Balsamo, Sandor
da Mota, Licia Maria Henrique
de Carvalho, Jozélio Freire
Nascimento, Dahan da Cunha
Tibana, Ramires Alsamir
Santos de Santana, Frederico
Moreno, Ricardo Lima
Gualano, Bruno
dos Santos-Neto, Leopoldo
author_sort Balsamo, Sandor
collection PubMed
description BACKGROUND: The purpose of the present study was to compare dynamic muscle strength, functional performance, fatigue, and quality of life in premenopausal systemic lupus erythematosus (SLE) patients with low disease activity versus matched-healthy controls and to determine the association of dynamic muscle strength with fatigue, functional performance, and quality of life in SLE patients. METHODS: We evaluated premenopausal (18–45 years) SLE patients with low disease activity (Systemic lupus erythematosus disease activity index [SLEDAI]: mean 1.5 ± 1.2). The control (n = 25) and patient (n = 25) groups were matched by age, physical characteristics, and the level of physical activities in daily life (International Physical Activity Questionnaire IPAQ). Both groups had not participated in regular exercise programs for at least six months prior to the study. Dynamic muscle strength was assessed by one-repetition maximum (1-RM) tests. Functional performance was assessed by the Timed Up and Go (TUG), in 30-s test a chair stand and arm curl using a 2-kg dumbbell and balance test, handgrip strength and a sit-and-reach flexibility test. Quality of life (SF-36) and fatigue were also measured. RESULTS: The SLE patients showed significantly lower dynamic muscle strength in all exercises (leg press 25.63%, leg extension 11.19%, leg curl 15.71%, chest press 18.33%, lat pulldown 13.56%, 1-RM total load 18.12%, P < 0.001-0.02) compared to the controls. The SLE patients also had lower functional performance, greater fatigue and poorer quality of life. In addition, fatigue, SF-36 and functional performance accounted for 52% of the variance in dynamic muscle strength in the SLE patients. CONCLUSIONS: Premenopausal SLE patients with low disease activity showed lower dynamic muscle strength, along with increased fatigue, reduced functional performance, and poorer quality of life when compared to matched controls.
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spelling pubmed-38471352013-12-07 Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study Balsamo, Sandor da Mota, Licia Maria Henrique de Carvalho, Jozélio Freire Nascimento, Dahan da Cunha Tibana, Ramires Alsamir Santos de Santana, Frederico Moreno, Ricardo Lima Gualano, Bruno dos Santos-Neto, Leopoldo BMC Musculoskelet Disord Research Article BACKGROUND: The purpose of the present study was to compare dynamic muscle strength, functional performance, fatigue, and quality of life in premenopausal systemic lupus erythematosus (SLE) patients with low disease activity versus matched-healthy controls and to determine the association of dynamic muscle strength with fatigue, functional performance, and quality of life in SLE patients. METHODS: We evaluated premenopausal (18–45 years) SLE patients with low disease activity (Systemic lupus erythematosus disease activity index [SLEDAI]: mean 1.5 ± 1.2). The control (n = 25) and patient (n = 25) groups were matched by age, physical characteristics, and the level of physical activities in daily life (International Physical Activity Questionnaire IPAQ). Both groups had not participated in regular exercise programs for at least six months prior to the study. Dynamic muscle strength was assessed by one-repetition maximum (1-RM) tests. Functional performance was assessed by the Timed Up and Go (TUG), in 30-s test a chair stand and arm curl using a 2-kg dumbbell and balance test, handgrip strength and a sit-and-reach flexibility test. Quality of life (SF-36) and fatigue were also measured. RESULTS: The SLE patients showed significantly lower dynamic muscle strength in all exercises (leg press 25.63%, leg extension 11.19%, leg curl 15.71%, chest press 18.33%, lat pulldown 13.56%, 1-RM total load 18.12%, P < 0.001-0.02) compared to the controls. The SLE patients also had lower functional performance, greater fatigue and poorer quality of life. In addition, fatigue, SF-36 and functional performance accounted for 52% of the variance in dynamic muscle strength in the SLE patients. CONCLUSIONS: Premenopausal SLE patients with low disease activity showed lower dynamic muscle strength, along with increased fatigue, reduced functional performance, and poorer quality of life when compared to matched controls. BioMed Central 2013-09-08 /pmc/articles/PMC3847135/ /pubmed/24011222 http://dx.doi.org/10.1186/1471-2474-14-263 Text en Copyright © 2013 Balsamo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Balsamo, Sandor
da Mota, Licia Maria Henrique
de Carvalho, Jozélio Freire
Nascimento, Dahan da Cunha
Tibana, Ramires Alsamir
Santos de Santana, Frederico
Moreno, Ricardo Lima
Gualano, Bruno
dos Santos-Neto, Leopoldo
Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
title Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
title_full Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
title_fullStr Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
title_full_unstemmed Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
title_short Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
title_sort low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847135/
https://www.ncbi.nlm.nih.gov/pubmed/24011222
http://dx.doi.org/10.1186/1471-2474-14-263
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