Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase

BACKGROUND: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are one of the key components in highly active anti-retroviral therapy because of their high specificity and less toxicity. NNRTIs inhibit reverse transcriptase enzyme by binding to the allosteric site, which is 10Å away from the a...

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Detalles Bibliográficos
Autores principales: Penta, Ashok, Ganguly, Swastika, Murugesan, Sankaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847232/
https://www.ncbi.nlm.nih.gov/pubmed/23968361
http://dx.doi.org/10.1186/2191-2858-3-8

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