Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy

Methotrexate (MTX) may have adverse effects on multiple organs and system. A few cases of pulmonary tuberculosis in-patients with rheumatoid arthritis (RA) while receiving MTX monotherapy has been reported in the literature. We submit a case of vertebral tuberculosis with hypercalcemia in a patient...

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Autores principales: Zorlu, Mehmet, Kiskac, Muharrem, Karatoprak, Cumali, Cakirca, Mustafa, Yavuz, Erdinç, Çetin, Güven, Çıkrıkçıoğlu, Mehmet Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847260/
https://www.ncbi.nlm.nih.gov/pubmed/24347778
http://dx.doi.org/10.4103/0253-7613.121385
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author Zorlu, Mehmet
Kiskac, Muharrem
Karatoprak, Cumali
Cakirca, Mustafa
Yavuz, Erdinç
Çetin, Güven
Çıkrıkçıoğlu, Mehmet Ali
author_facet Zorlu, Mehmet
Kiskac, Muharrem
Karatoprak, Cumali
Cakirca, Mustafa
Yavuz, Erdinç
Çetin, Güven
Çıkrıkçıoğlu, Mehmet Ali
author_sort Zorlu, Mehmet
collection PubMed
description Methotrexate (MTX) may have adverse effects on multiple organs and system. A few cases of pulmonary tuberculosis in-patients with rheumatoid arthritis (RA) while receiving MTX monotherapy has been reported in the literature. We submit a case of vertebral tuberculosis with hypercalcemia in a patient receiving MTX monotherapy. Patient with RA taking MTX for 15 years developed pancytopenia, skin necrosis, tuberculous spondylodiscitis and hypercalcemia. The present case showed adverse effects of MTX therapy may occur even after years of continuous treatment. Due to pancytopenia in older patients, life-threatening tuberculosis at unusual sites may develop.
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spelling pubmed-38472602013-12-16 Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy Zorlu, Mehmet Kiskac, Muharrem Karatoprak, Cumali Cakirca, Mustafa Yavuz, Erdinç Çetin, Güven Çıkrıkçıoğlu, Mehmet Ali Indian J Pharmacol Drug Watch Methotrexate (MTX) may have adverse effects on multiple organs and system. A few cases of pulmonary tuberculosis in-patients with rheumatoid arthritis (RA) while receiving MTX monotherapy has been reported in the literature. We submit a case of vertebral tuberculosis with hypercalcemia in a patient receiving MTX monotherapy. Patient with RA taking MTX for 15 years developed pancytopenia, skin necrosis, tuberculous spondylodiscitis and hypercalcemia. The present case showed adverse effects of MTX therapy may occur even after years of continuous treatment. Due to pancytopenia in older patients, life-threatening tuberculosis at unusual sites may develop. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3847260/ /pubmed/24347778 http://dx.doi.org/10.4103/0253-7613.121385 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Zorlu, Mehmet
Kiskac, Muharrem
Karatoprak, Cumali
Cakirca, Mustafa
Yavuz, Erdinç
Çetin, Güven
Çıkrıkçıoğlu, Mehmet Ali
Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
title Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
title_full Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
title_fullStr Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
title_full_unstemmed Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
title_short Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
title_sort pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847260/
https://www.ncbi.nlm.nih.gov/pubmed/24347778
http://dx.doi.org/10.4103/0253-7613.121385
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