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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been p...

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Detalles Bibliográficos
Autores principales: Gong, Lauren, Parikh, Sunil, Rosenthal, Philip J, Greenhouse, Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847285/
https://www.ncbi.nlm.nih.gov/pubmed/24025776
http://dx.doi.org/10.1186/1475-2875-12-317
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author Gong, Lauren
Parikh, Sunil
Rosenthal, Philip J
Greenhouse, Bryan
author_facet Gong, Lauren
Parikh, Sunil
Rosenthal, Philip J
Greenhouse, Bryan
author_sort Gong, Lauren
collection PubMed
description Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.
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spelling pubmed-38472852013-12-04 Biochemical and immunological mechanisms by which sickle cell trait protects against malaria Gong, Lauren Parikh, Sunil Rosenthal, Philip J Greenhouse, Bryan Malar J Review Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria. BioMed Central 2013-09-11 /pmc/articles/PMC3847285/ /pubmed/24025776 http://dx.doi.org/10.1186/1475-2875-12-317 Text en Copyright © 2013 Gong et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gong, Lauren
Parikh, Sunil
Rosenthal, Philip J
Greenhouse, Bryan
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
title Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
title_full Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
title_fullStr Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
title_full_unstemmed Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
title_short Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
title_sort biochemical and immunological mechanisms by which sickle cell trait protects against malaria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847285/
https://www.ncbi.nlm.nih.gov/pubmed/24025776
http://dx.doi.org/10.1186/1475-2875-12-317
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