(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease

Genetic and epidemiologic evidence suggests that cellular energy homeostasis is critically associated with Parkinson's disease (PD) pathogenesis. Here we demonstrated that genetic deletion of Poly (ADP-ribose) polymerase 1 completely blocked 6-hydroxydopamine-induced dopaminergic neurodegenerat...

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Detalles Bibliográficos
Autores principales: Kim, T W, Cho, H M, Choi, S Y, Suguira, Y, Hayasaka, T, Setou, M, Koh, H C, Mi Hwang, E, Park, J Y, Kang, S J, Kim, H S, Kim, H, Sun, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847323/
https://www.ncbi.nlm.nih.gov/pubmed/24232095
http://dx.doi.org/10.1038/cddis.2013.447

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