Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

Smac mimetics (SMs) comprise a class of small molecules that target members of the inhibitor of apoptosis family of pro-survival proteins, whose expression in cancer cells hinders the action of conventional chemotherapeutics. Herein, we describe the activity of SM83, a newly synthesised dimeric SM,...

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Detalles Bibliográficos
Autores principales: Lecis, D, De Cesare, M, Perego, P, Conti, A, Corna, E, Drago, C, Seneci, P, Walczak, H, Colombo, M P, Delia, D, Sangaletti, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847325/
https://www.ncbi.nlm.nih.gov/pubmed/24232096
http://dx.doi.org/10.1038/cddis.2013.449

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