Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells

Endoplasmic reticulum (ER) is a central organelle in eukaryotic cells that regulates protein synthesis and maturation. Perturbation of ER functions leads to ER stress, which has been previously associated with a broad variety of diseases. ER stress is generally regarded as compensatory, but prolonge...

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Detalles Bibliográficos
Autores principales: Sanchez-Lopez, E, Zimmerman, T, Gomez del Pulgar, T, Moyer, M P, Lacal Sanjuan, J C, Cebrian, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847329/
https://www.ncbi.nlm.nih.gov/pubmed/24287694
http://dx.doi.org/10.1038/cddis.2013.453

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