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Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus

BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, cause protein carbonylation and mitochondrial dysfunction, forming advanced glyc...

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Detalles Bibliográficos
Autores principales:	Morita, Kazunori, Saruwatari, Junji, Miyagawa, Haruna, Uchiyashiki, Yoshihiro, Oniki, Kentaro, Sakata, Misaki, Kajiwara, Ayami, Yoshida, Akira, Jinnouchi, Hideaki, Nakagawa, Kazuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847457/ https://www.ncbi.nlm.nih.gov/pubmed/24028448 http://dx.doi.org/10.1186/1475-2840-12-132

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