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Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study

BACKGROUND: T1 imaging based on pixel-wise quantification of longitudinal relaxation has the potential to differentiate between normal and abnormal myocardium. The accuracy of T1 measurement has not been established nor systematically tested in the presence of health and disease. METHODS: Intra-obse...

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Autores principales: Rogers, Toby, Dabir, Darius, Mahmoud, Islam, Voigt, Tobias, Schaeffter, Tobias, Nagel, Eike, Puntmann, Valentina O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847466/
https://www.ncbi.nlm.nih.gov/pubmed/24025486
http://dx.doi.org/10.1186/1532-429X-15-78
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author Rogers, Toby
Dabir, Darius
Mahmoud, Islam
Voigt, Tobias
Schaeffter, Tobias
Nagel, Eike
Puntmann, Valentina O
author_facet Rogers, Toby
Dabir, Darius
Mahmoud, Islam
Voigt, Tobias
Schaeffter, Tobias
Nagel, Eike
Puntmann, Valentina O
author_sort Rogers, Toby
collection PubMed
description BACKGROUND: T1 imaging based on pixel-wise quantification of longitudinal relaxation has the potential to differentiate between normal and abnormal myocardium. The accuracy of T1 measurement has not been established nor systematically tested in the presence of health and disease. METHODS: Intra-observer, inter-observer and inter-study reproducibility of T1 imaging was assessed in subjects with left ventricular hypertrophy (LVH, n = 25) or dilated cardiomyopathy (DCM, n = 43). Thirty-eight subjects with low-pretest likelihood of cardiomyopathy served as a control group. T1 values were acquired in a single mid-ventricular short axis slice using modified Look-Locker imaging prior and after the application of gadolinium contrast at 1.5 and 3 T. Analysis was performed with regions of interest (ROI) placed conservatively within the septum or to include the whole short axis (SAX) myocardium. RESULTS: Intra-observer, inter-observer and inter-study repeated measurements within the septum showed smaller mean differences and narrower 95% confidence intervals than repeated short axis ROI measurements. Native T1 values were higher in septal ROIs compared with SAX values at both field strengths (1.5 T: 976 ± 37 vs. 952 ± 41, p < 0.01; 3 T: 1108 ± 67 vs. 1087 ± 60, p < 0.01). Native T1 values revealed significant mean differences between controls and patients with LVH for both septal (1.5 T: 26 ± 9, p < 0.01; 3 T: 50 ± 13, p < 0.01) and SAX ROIs (1.5 T: 19 ± 11, p < 0.05; 3 T: 47 ± 19, p < 0.05) with greater differences observed at 3 T versus 1.5 T field strength. Native T1 values revealed significant mean differences between controls and patients with DCM for septal ROI (1.5 T: 29 ± 15, p < 0.05; 3 T: 55 ± 16, p < 0.01) at both 1.5 T and 3 T, but only for SAX ROIs at 3 T (49 ± 17, p < 0.01). There were no significant differences in post-contrast T1 values or partition coefficient (λ) between controls and patients. CONCLUSION: Conservative septal ROI T1 measurement is a robust technique with excellent intra-observer, inter-observer and inter-study reproducibility for native and post-contrast T1 value and partition coefficient measurements. Moreover, native septal T1 values reveal the greatest difference between normal and abnormal myocardium, which is independent of geometrical alterations of cardiac chamber and wall thickness. We propose the use of native T1 measurements using conservative septal technique as the standardized approach to distinguish health from disease assuming diffuse myocardial involvement.
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spelling pubmed-38474662013-12-04 Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study Rogers, Toby Dabir, Darius Mahmoud, Islam Voigt, Tobias Schaeffter, Tobias Nagel, Eike Puntmann, Valentina O J Cardiovasc Magn Reson Research BACKGROUND: T1 imaging based on pixel-wise quantification of longitudinal relaxation has the potential to differentiate between normal and abnormal myocardium. The accuracy of T1 measurement has not been established nor systematically tested in the presence of health and disease. METHODS: Intra-observer, inter-observer and inter-study reproducibility of T1 imaging was assessed in subjects with left ventricular hypertrophy (LVH, n = 25) or dilated cardiomyopathy (DCM, n = 43). Thirty-eight subjects with low-pretest likelihood of cardiomyopathy served as a control group. T1 values were acquired in a single mid-ventricular short axis slice using modified Look-Locker imaging prior and after the application of gadolinium contrast at 1.5 and 3 T. Analysis was performed with regions of interest (ROI) placed conservatively within the septum or to include the whole short axis (SAX) myocardium. RESULTS: Intra-observer, inter-observer and inter-study repeated measurements within the septum showed smaller mean differences and narrower 95% confidence intervals than repeated short axis ROI measurements. Native T1 values were higher in septal ROIs compared with SAX values at both field strengths (1.5 T: 976 ± 37 vs. 952 ± 41, p < 0.01; 3 T: 1108 ± 67 vs. 1087 ± 60, p < 0.01). Native T1 values revealed significant mean differences between controls and patients with LVH for both septal (1.5 T: 26 ± 9, p < 0.01; 3 T: 50 ± 13, p < 0.01) and SAX ROIs (1.5 T: 19 ± 11, p < 0.05; 3 T: 47 ± 19, p < 0.05) with greater differences observed at 3 T versus 1.5 T field strength. Native T1 values revealed significant mean differences between controls and patients with DCM for septal ROI (1.5 T: 29 ± 15, p < 0.05; 3 T: 55 ± 16, p < 0.01) at both 1.5 T and 3 T, but only for SAX ROIs at 3 T (49 ± 17, p < 0.01). There were no significant differences in post-contrast T1 values or partition coefficient (λ) between controls and patients. CONCLUSION: Conservative septal ROI T1 measurement is a robust technique with excellent intra-observer, inter-observer and inter-study reproducibility for native and post-contrast T1 value and partition coefficient measurements. Moreover, native septal T1 values reveal the greatest difference between normal and abnormal myocardium, which is independent of geometrical alterations of cardiac chamber and wall thickness. We propose the use of native T1 measurements using conservative septal technique as the standardized approach to distinguish health from disease assuming diffuse myocardial involvement. BioMed Central 2013-09-11 /pmc/articles/PMC3847466/ /pubmed/24025486 http://dx.doi.org/10.1186/1532-429X-15-78 Text en Copyright © 2013 Rogers et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rogers, Toby
Dabir, Darius
Mahmoud, Islam
Voigt, Tobias
Schaeffter, Tobias
Nagel, Eike
Puntmann, Valentina O
Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study
title Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study
title_full Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study
title_fullStr Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study
title_full_unstemmed Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study
title_short Standardization of T1 measurements with MOLLI in differentiation between health and disease – the ConSept study
title_sort standardization of t1 measurements with molli in differentiation between health and disease – the consept study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847466/
https://www.ncbi.nlm.nih.gov/pubmed/24025486
http://dx.doi.org/10.1186/1532-429X-15-78
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