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Effect of enhanced external counterpulsation treatment on renal function in cardiac patients

BACKGROUND: Enhanced external counterpulsation (EECP) enhances coronary perfusion and reduces left ventricular afterload. However, the role of EECP on renal function in cardiac patients is unknown. Our aim was to assess renal function determined by serum cystatin C in cardiac patients before and aft...

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Autores principales: Ruangkanchanasetr, Prajej, Mahanonda, Nithi, Raungratanaamporn, Ongkarn, Ruckpanich, Piyanuj, Kitiyakara, Chagriya, Chaiprasert, Amnart, Adirekkiat, Surawat, Punpanich, Dollapas, Vanavanan, Somlak, Chittamma, Anchalee, Supaporn, Thanom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847607/
https://www.ncbi.nlm.nih.gov/pubmed/24021027
http://dx.doi.org/10.1186/1471-2369-14-193
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author Ruangkanchanasetr, Prajej
Mahanonda, Nithi
Raungratanaamporn, Ongkarn
Ruckpanich, Piyanuj
Kitiyakara, Chagriya
Chaiprasert, Amnart
Adirekkiat, Surawat
Punpanich, Dollapas
Vanavanan, Somlak
Chittamma, Anchalee
Supaporn, Thanom
author_facet Ruangkanchanasetr, Prajej
Mahanonda, Nithi
Raungratanaamporn, Ongkarn
Ruckpanich, Piyanuj
Kitiyakara, Chagriya
Chaiprasert, Amnart
Adirekkiat, Surawat
Punpanich, Dollapas
Vanavanan, Somlak
Chittamma, Anchalee
Supaporn, Thanom
author_sort Ruangkanchanasetr, Prajej
collection PubMed
description BACKGROUND: Enhanced external counterpulsation (EECP) enhances coronary perfusion and reduces left ventricular afterload. However, the role of EECP on renal function in cardiac patients is unknown. Our aim was to assess renal function determined by serum cystatin C in cardiac patients before and after EECP treatment. METHODS: A prospective observational longitudinal study was conducted in order to evaluate renal function using serum cystatin C (Cys C) and estimated glomerular filtration rate (GFR) after 35 sessions of EECP treatment in 30 patients with chronic stable angina and/or heart failure. The median (IQR) time for follow-up period after starting EECP treatment was 16 (10–24) months. RESULTS: Cys C significantly declined from 1.00 (0.78-1.31) to 0.94 (0.77-1.27) mg/L (p < 0.001) and estimated GFR increased from 70.47 (43.88-89.41) to 76.27 (49.02-91.46) mL/min/1.73 m(2) (p = 0.006) after EECP treatment. Subgroup analysis showed that patients with baseline GFR <60 mL/min/1.73 m(2) or NT-proBNP >125 pg/mL had a significant decrease in Cys C when compared to other groups (p < 0.01). CONCLUSIONS: The study demonstrated that EECP could improve long-term renal function in cardiac patients especially in cases with declined renal function or with high NT-proBNP. TRIAL REGISTRATION: The study was registered in the clinical trial as International Standard Randomized Controlled Trial Number ISRCTN11560035.
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spelling pubmed-38476072013-12-04 Effect of enhanced external counterpulsation treatment on renal function in cardiac patients Ruangkanchanasetr, Prajej Mahanonda, Nithi Raungratanaamporn, Ongkarn Ruckpanich, Piyanuj Kitiyakara, Chagriya Chaiprasert, Amnart Adirekkiat, Surawat Punpanich, Dollapas Vanavanan, Somlak Chittamma, Anchalee Supaporn, Thanom BMC Nephrol Research Article BACKGROUND: Enhanced external counterpulsation (EECP) enhances coronary perfusion and reduces left ventricular afterload. However, the role of EECP on renal function in cardiac patients is unknown. Our aim was to assess renal function determined by serum cystatin C in cardiac patients before and after EECP treatment. METHODS: A prospective observational longitudinal study was conducted in order to evaluate renal function using serum cystatin C (Cys C) and estimated glomerular filtration rate (GFR) after 35 sessions of EECP treatment in 30 patients with chronic stable angina and/or heart failure. The median (IQR) time for follow-up period after starting EECP treatment was 16 (10–24) months. RESULTS: Cys C significantly declined from 1.00 (0.78-1.31) to 0.94 (0.77-1.27) mg/L (p < 0.001) and estimated GFR increased from 70.47 (43.88-89.41) to 76.27 (49.02-91.46) mL/min/1.73 m(2) (p = 0.006) after EECP treatment. Subgroup analysis showed that patients with baseline GFR <60 mL/min/1.73 m(2) or NT-proBNP >125 pg/mL had a significant decrease in Cys C when compared to other groups (p < 0.01). CONCLUSIONS: The study demonstrated that EECP could improve long-term renal function in cardiac patients especially in cases with declined renal function or with high NT-proBNP. TRIAL REGISTRATION: The study was registered in the clinical trial as International Standard Randomized Controlled Trial Number ISRCTN11560035. BioMed Central 2013-09-11 /pmc/articles/PMC3847607/ /pubmed/24021027 http://dx.doi.org/10.1186/1471-2369-14-193 Text en Copyright © 2013 Ruangkanchanasetr et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ruangkanchanasetr, Prajej
Mahanonda, Nithi
Raungratanaamporn, Ongkarn
Ruckpanich, Piyanuj
Kitiyakara, Chagriya
Chaiprasert, Amnart
Adirekkiat, Surawat
Punpanich, Dollapas
Vanavanan, Somlak
Chittamma, Anchalee
Supaporn, Thanom
Effect of enhanced external counterpulsation treatment on renal function in cardiac patients
title Effect of enhanced external counterpulsation treatment on renal function in cardiac patients
title_full Effect of enhanced external counterpulsation treatment on renal function in cardiac patients
title_fullStr Effect of enhanced external counterpulsation treatment on renal function in cardiac patients
title_full_unstemmed Effect of enhanced external counterpulsation treatment on renal function in cardiac patients
title_short Effect of enhanced external counterpulsation treatment on renal function in cardiac patients
title_sort effect of enhanced external counterpulsation treatment on renal function in cardiac patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847607/
https://www.ncbi.nlm.nih.gov/pubmed/24021027
http://dx.doi.org/10.1186/1471-2369-14-193
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