Cargando…

Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor

Detalles Bibliográficos
Autores principales:	Corona, Angela, Meleddu, Rita, Esposito, Francesca, Distinto, Simona, Bianco, Giulia, Maccioni, Elias, Le Grice, Stuart SF, Tramontano, Enzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847829/ http://dx.doi.org/10.1186/1742-4690-10-S1-P19

Ejemplares similares

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6
por: Corona, Angela, et al.
Publicado: (2016)

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions
por: Meleddu, Rita, et al.
Publicado: (2021)

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
por: Meleddu, Rita, et al.
Publicado: (2016)

Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
por: Fois, Benedetta, et al.
Publicado: (2021)

5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
por: Corona, Angela, et al.
Publicado: (2023)

Impact of human immunodeficiency virus type 1 ribonuclease H inhibitors on the polymerase and RNase H function of foamy virus reverse transcriptase
por: Corona, Angela, et al.
Publicado: (2013)

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
por: Massari, Serena, et al.
Publicado: (2018)

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase
por: Messore, Antonella, et al.
Publicado: (2021)

Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H
por: Tocco, Graziella, et al.
Publicado: (2020)

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain
por: Carcelli, Mauro, et al.
Publicado: (2017)

Comparison of Reverse Transcriptase (RT) Activities of Various M-MuLV RTs for RT-LAMP Assays
por: Oscorbin, Igor P., et al.
Publicado: (2022)

HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions
por: Esposito, Francesca, et al.
Publicado: (2012)

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
por: Meleddu, Rita, et al.
Publicado: (2017)

Simplified visual detection of Kyasanur Forest Disease virus employing Reverse Transcriptase-Polymerase Spiral Reaction (RT-PSR)
por: Yadav, Pooja, et al.
Publicado: (2023)

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
por: Melis, Claudia, et al.
Publicado: (2016)

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
por: Desantis, Jenny, et al.
Publicado: (2020)

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
por: Boyer, Paul L., et al.
Publicado: (2019)

2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication
por: Corona, Angela, et al.
Publicado: (2020)

The Agreement Between Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) and Rapid Antigen Test (RAT) in Diagnosing COVID-19
por: Sahu, Rupesh, et al.
Publicado: (2022)

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors
por: Fisher, Timothy S, et al.
Publicado: (2005)

Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids
por: Dash, Chandravanu, et al.
Publicado: (2008)

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
por: Budihas, Scott R., et al.
Publicado: (2005)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

Heminested reverse-transcriptase polymerase chain reaction (hnRT-PCR) as a tool for rabies virus detection in stored and decomposed samples
por: Araújo, Danielle B, et al.
Publicado: (2008)

Hot start reverse transcriptase: an approach for improved real-time RT-PCR performance
por: Rutschke, Nils, et al.
Publicado: (2015)

Factors associated with weak positive SARS-CoV-2 diagnosis by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR)
por: Rawat, Priyank, et al.
Publicado: (2022)

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity
por: Ilina, Tatiana, et al.
Publicado: (2012)

A comparative analysis of routine techniques: Reverse transcriptase polymerase chain reaction (RT-PCR) and five cell lines for detection of enteroviruses in stool specimens
por: Abbasian, F, et al.
Publicado: (2011)

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms
por: Bianco, Giulia, et al.
Publicado: (2017)

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)
por: Harrison, Jerry Joe E. K., et al.
Publicado: (2021)

The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
por: Abram, Michael E, et al.
Publicado: (2010)

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition
por: Baldwin, Eric T., et al.
Publicado: (2022)

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds
por: Sanna, Cinzia, et al.
Publicado: (2021)

Application of Reverse Transcriptase –PCR (RT-PCR) for rapid detection of viable Escherichia coli in drinking water samples
por: Molaee, Neda, et al.
Publicado: (2015)

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies
por: Singh, Abhimanyu K., et al.
Publicado: (2022)

Variation of Human Immunodeficiency Virus Type-1 Reverse Transcriptase within the Simian Immunodeficiency Virus Genome of RT-SHIV
por: Wadford, Debra A., et al.
Publicado: (2014)

Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)
por: Ledezma, Carlos E., et al.
Publicado: (2020)

Application of in situ reverse trancriptase-polymerase chain reaction (RT-PCR) to tissue microarrays
por: Stamps, Alasdair C, et al.
Publicado: (2003)

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation
por: Zheng, Xunhai, et al.
Publicado: (2014)

Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation
por: Fois, Benedetta, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qn9o666frtfslo9aacur8atmgd