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Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
During development of the central nervous system the Wnt signaling pathway has been implicated in a wide spectrum of physiological processes, including neuronal connectivity and synapse formation. Wnt proteins and components of the Wnt pathway are expressed in the brain since early development to th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847898/ https://www.ncbi.nlm.nih.gov/pubmed/24348327 http://dx.doi.org/10.3389/fncel.2013.00224 |
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author | Oliva, Carolina A. Vargas, Jessica Y. Inestrosa, Nibaldo C. |
author_facet | Oliva, Carolina A. Vargas, Jessica Y. Inestrosa, Nibaldo C. |
author_sort | Oliva, Carolina A. |
collection | PubMed |
description | During development of the central nervous system the Wnt signaling pathway has been implicated in a wide spectrum of physiological processes, including neuronal connectivity and synapse formation. Wnt proteins and components of the Wnt pathway are expressed in the brain since early development to the adult life, however, little is known about its role in mature synapses. Here, we review evidences indicating that Wnt proteins participate in the remodeling of pre- and post-synaptic regions, thus modulating synaptic function. We include the most recent data in the literature showing that Wnts are constantly released in the brain to maintain the basal neural activity. Also, we review the evidences that involve components of the Wnt pathway in the development of neurological and mental disorders, including a special emphasis on in vivo studies that relate behavioral abnormalities to deficiencies in Wnt signaling. Finally, we include the evidences that support a neuroprotective role of Wnt proteins in Alzheimer’s disease. We postulate that deregulation in Wnt signaling might have a fundamental role in the origin of neurological diseases, by altering the synaptic function at stages where the phenotype is not yet established but when the cognitive decline starts. |
format | Online Article Text |
id | pubmed-3847898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38478982013-12-17 Wnts in adult brain: from synaptic plasticity to cognitive deficiencies Oliva, Carolina A. Vargas, Jessica Y. Inestrosa, Nibaldo C. Front Cell Neurosci Neuroscience During development of the central nervous system the Wnt signaling pathway has been implicated in a wide spectrum of physiological processes, including neuronal connectivity and synapse formation. Wnt proteins and components of the Wnt pathway are expressed in the brain since early development to the adult life, however, little is known about its role in mature synapses. Here, we review evidences indicating that Wnt proteins participate in the remodeling of pre- and post-synaptic regions, thus modulating synaptic function. We include the most recent data in the literature showing that Wnts are constantly released in the brain to maintain the basal neural activity. Also, we review the evidences that involve components of the Wnt pathway in the development of neurological and mental disorders, including a special emphasis on in vivo studies that relate behavioral abnormalities to deficiencies in Wnt signaling. Finally, we include the evidences that support a neuroprotective role of Wnt proteins in Alzheimer’s disease. We postulate that deregulation in Wnt signaling might have a fundamental role in the origin of neurological diseases, by altering the synaptic function at stages where the phenotype is not yet established but when the cognitive decline starts. Frontiers Media S.A. 2013-12-03 /pmc/articles/PMC3847898/ /pubmed/24348327 http://dx.doi.org/10.3389/fncel.2013.00224 Text en Copyright © 2013 Oliva, Vargas and Inestrosa. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Oliva, Carolina A. Vargas, Jessica Y. Inestrosa, Nibaldo C. Wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
title | Wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
title_full | Wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
title_fullStr | Wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
title_full_unstemmed | Wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
title_short | Wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
title_sort | wnts in adult brain: from synaptic plasticity to cognitive deficiencies |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847898/ https://www.ncbi.nlm.nih.gov/pubmed/24348327 http://dx.doi.org/10.3389/fncel.2013.00224 |
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