Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, ad...

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Autores principales: Velusami, Chandrasekaran Chinampudur, Agarwal, Amit, Mookambeswaran, Vijayalakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848046/
https://www.ncbi.nlm.nih.gov/pubmed/24348689
http://dx.doi.org/10.1155/2013/145925
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author Velusami, Chandrasekaran Chinampudur
Agarwal, Amit
Mookambeswaran, Vijayalakshmi
author_facet Velusami, Chandrasekaran Chinampudur
Agarwal, Amit
Mookambeswaran, Vijayalakshmi
author_sort Velusami, Chandrasekaran Chinampudur
collection PubMed
description N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT(2C)), cannabinoid (CNR(2)), melanocyte concentrating hormone (MCHR(1)), and melanocortin (MC(4)R) receptors. Both methanol and successive water extracts of N. nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis. N. nucifera petal methanol extract exhibited the concentration-dependent inhibitory effect on lipase activity with an IC(50) value of 47 µg/mL. N. nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT(2C) and CNR(2) receptors, respectively, while it showed no effect towards MCHR(1) and MC(4)R receptors. Overall, methanol extract of N. nucifera petals showed better activity than successive water extract.
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spelling pubmed-38480462013-12-12 Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity Velusami, Chandrasekaran Chinampudur Agarwal, Amit Mookambeswaran, Vijayalakshmi Evid Based Complement Alternat Med Research Article N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT(2C)), cannabinoid (CNR(2)), melanocyte concentrating hormone (MCHR(1)), and melanocortin (MC(4)R) receptors. Both methanol and successive water extracts of N. nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis. N. nucifera petal methanol extract exhibited the concentration-dependent inhibitory effect on lipase activity with an IC(50) value of 47 µg/mL. N. nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT(2C) and CNR(2) receptors, respectively, while it showed no effect towards MCHR(1) and MC(4)R receptors. Overall, methanol extract of N. nucifera petals showed better activity than successive water extract. Hindawi Publishing Corporation 2013 2013-11-14 /pmc/articles/PMC3848046/ /pubmed/24348689 http://dx.doi.org/10.1155/2013/145925 Text en Copyright © 2013 Chandrasekaran Chinampudur Velusami et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Velusami, Chandrasekaran Chinampudur
Agarwal, Amit
Mookambeswaran, Vijayalakshmi
Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
title Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
title_full Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
title_fullStr Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
title_full_unstemmed Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
title_short Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
title_sort effect of nelumbo nucifera petal extracts on lipase, adipogenesis, adipolysis, and central receptors of obesity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848046/
https://www.ncbi.nlm.nih.gov/pubmed/24348689
http://dx.doi.org/10.1155/2013/145925
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AT mookambeswaranvijayalakshmi effectofnelumbonuciferapetalextractsonlipaseadipogenesisadipolysisandcentralreceptorsofobesity

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