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Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

BACKGROUND: Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation of the VHL tumour suppressor gene (TSG), inactivation of chromosome 3p TSGs im...

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Detalles Bibliográficos
Autores principales:	Ricketts, Christopher J, Morris, Mark R, Gentle, Dean, Shuib, Salwati, Brown, Michael, Clarke, Noel, Wei, Wenbin, Nathan, Paul, Latif, Farida, Maher, Eamonn R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848591/ https://www.ncbi.nlm.nih.gov/pubmed/24034811 http://dx.doi.org/10.1186/1868-7083-5-16

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