Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

BACKGROUND: Naphthoquinones (NQs) are privileged structures in medicinal chemistry due to the biological effects associated with the induction of oxidative stress. The present study evaluated the activities of sixteen NQs derivatives on Trypanosoma cruzi. RESULTS: Fourteen NQs displayed higher activ...

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Detalles Bibliográficos
Autores principales: Salomão, Kelly, De Santana, Natalia A, Molina, Maria Teresa, De Castro, Solange L, Menna-Barreto, Rubem F S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848626/
https://www.ncbi.nlm.nih.gov/pubmed/24004461
http://dx.doi.org/10.1186/1471-2180-13-196

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