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Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response

BACKGROUND: Mediating DNA damage-induced apoptosis is an important genome-maintenance function of the mismatch repair (MMR) system. Defects in MMR not only cause carcinogenesis, but also render cancer cells highly resistant to chemotherapeutics, including alkylating agents. To understand the mechani...

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Detalles Bibliográficos
Autores principales:	Chen, Xi, Zhao, Yong, Li, Guo-Min, Guo, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848634/ https://www.ncbi.nlm.nih.gov/pubmed/24330662 http://dx.doi.org/10.1186/2045-3701-3-37

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