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The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication

BACKGROUND: HIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic translation Initiation Factor 2 (eIF2α), which decreases viral replication. The...

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Detalles Bibliográficos
Autores principales:	Clerzius, Guerline, Shaw, Eileen, Daher, Aïcha, Burugu, Samantha, Gélinas, Jean-François, Ear, Thornin, Sinck, Lucile, Routy, Jean-Pierre, Mouland, Andrew J, Patel, Rekha C, Gatignol, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848765/ https://www.ncbi.nlm.nih.gov/pubmed/24020926 http://dx.doi.org/10.1186/1742-4690-10-96

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