Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases

Treatment of anorectal Buschke-Löwenstein tumor (BLT) with squamous cell carcinoma (SCC) transformation is not univocal given the rarity of the disease. BLT is characterized by its large size and tendency to infiltrate into underlying tissues. Malignant transformation can occur and it is important t...

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Autores principales: Indinnimeo, Marileda, Impagnatiello, Alessio, D’Ettorre, Gabriella, Bernardi, Gloria, Moschella, Cosima Maria, Gozzo, Paolo, Ciardi, Antonio, Bangrazi, Caterina, De Felice, Francesca, Musio, Daniela, Tombolini, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848791/
https://www.ncbi.nlm.nih.gov/pubmed/24040860
http://dx.doi.org/10.1186/1477-7819-11-231
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author Indinnimeo, Marileda
Impagnatiello, Alessio
D’Ettorre, Gabriella
Bernardi, Gloria
Moschella, Cosima Maria
Gozzo, Paolo
Ciardi, Antonio
Bangrazi, Caterina
De Felice, Francesca
Musio, Daniela
Tombolini, Vincenzo
author_facet Indinnimeo, Marileda
Impagnatiello, Alessio
D’Ettorre, Gabriella
Bernardi, Gloria
Moschella, Cosima Maria
Gozzo, Paolo
Ciardi, Antonio
Bangrazi, Caterina
De Felice, Francesca
Musio, Daniela
Tombolini, Vincenzo
author_sort Indinnimeo, Marileda
collection PubMed
description Treatment of anorectal Buschke-Löwenstein tumor (BLT) with squamous cell carcinoma (SCC) transformation is not univocal given the rarity of the disease. BLT is characterized by its large size and tendency to infiltrate into underlying tissues. Malignant transformation can occur and it is important to identify the presence of neoplastic foci to decide the proper treatment. Our aim was to assess the effectiveness of neo-adjuvant chemo-radiation therapy (CRT) and local excision in order to avoid abdomino-perineal resection (APR). Three cases of anorectal BLT with SCC transformation are presented. All patients were HIV positive and treated with antiretroviral drugs. They underwent preoperative endoanal ultrasound, biopsies, total body tomography and anal brushing. Treatment consisted of neo-adjuvant chemo-radiation therapy (45 Gy to the pelvis plus a boost with 14.40 Gy to the primary tumor for a total of 59.40 Gy, and mitomycin-C in bolus on the first day, plus 5-fluorouracil by continuous infusion in the first and in the sixth week) and subsequent local surgical excision. During the follow-up, patients were subjected to the same preoperative diagnostic investigations and high resolution anoscopy. All patients showed a complete regression of the lesion after CRT and were treated by local surgical excision, thus avoiding permanent colostomy. In conclusion neo-adjuvant chemo-radiation therapy with local surgical excision could be considered an effective therapy in the treatment of anorectal BLT with SCC transformation to avoid APR.
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spelling pubmed-38487912013-12-04 Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases Indinnimeo, Marileda Impagnatiello, Alessio D’Ettorre, Gabriella Bernardi, Gloria Moschella, Cosima Maria Gozzo, Paolo Ciardi, Antonio Bangrazi, Caterina De Felice, Francesca Musio, Daniela Tombolini, Vincenzo World J Surg Oncol Case Report Treatment of anorectal Buschke-Löwenstein tumor (BLT) with squamous cell carcinoma (SCC) transformation is not univocal given the rarity of the disease. BLT is characterized by its large size and tendency to infiltrate into underlying tissues. Malignant transformation can occur and it is important to identify the presence of neoplastic foci to decide the proper treatment. Our aim was to assess the effectiveness of neo-adjuvant chemo-radiation therapy (CRT) and local excision in order to avoid abdomino-perineal resection (APR). Three cases of anorectal BLT with SCC transformation are presented. All patients were HIV positive and treated with antiretroviral drugs. They underwent preoperative endoanal ultrasound, biopsies, total body tomography and anal brushing. Treatment consisted of neo-adjuvant chemo-radiation therapy (45 Gy to the pelvis plus a boost with 14.40 Gy to the primary tumor for a total of 59.40 Gy, and mitomycin-C in bolus on the first day, plus 5-fluorouracil by continuous infusion in the first and in the sixth week) and subsequent local surgical excision. During the follow-up, patients were subjected to the same preoperative diagnostic investigations and high resolution anoscopy. All patients showed a complete regression of the lesion after CRT and were treated by local surgical excision, thus avoiding permanent colostomy. In conclusion neo-adjuvant chemo-radiation therapy with local surgical excision could be considered an effective therapy in the treatment of anorectal BLT with SCC transformation to avoid APR. BioMed Central 2013-09-16 /pmc/articles/PMC3848791/ /pubmed/24040860 http://dx.doi.org/10.1186/1477-7819-11-231 Text en Copyright © 2013 Indinnimeo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Indinnimeo, Marileda
Impagnatiello, Alessio
D’Ettorre, Gabriella
Bernardi, Gloria
Moschella, Cosima Maria
Gozzo, Paolo
Ciardi, Antonio
Bangrazi, Caterina
De Felice, Francesca
Musio, Daniela
Tombolini, Vincenzo
Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
title Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
title_full Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
title_fullStr Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
title_full_unstemmed Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
title_short Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
title_sort buschke-löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848791/
https://www.ncbi.nlm.nih.gov/pubmed/24040860
http://dx.doi.org/10.1186/1477-7819-11-231
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