Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we...

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Detalles Bibliográficos
Autores principales: Samatov, Timur R, Tonevitsky, Alexander G, Schumacher, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848796/
https://www.ncbi.nlm.nih.gov/pubmed/24053443
http://dx.doi.org/10.1186/1476-4598-12-107
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author Samatov, Timur R
Tonevitsky, Alexander G
Schumacher, Udo
author_facet Samatov, Timur R
Tonevitsky, Alexander G
Schumacher, Udo
author_sort Samatov, Timur R
collection PubMed
description Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.
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spelling pubmed-38487962013-12-04 Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds Samatov, Timur R Tonevitsky, Alexander G Schumacher, Udo Mol Cancer Review Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy. BioMed Central 2013-09-23 /pmc/articles/PMC3848796/ /pubmed/24053443 http://dx.doi.org/10.1186/1476-4598-12-107 Text en Copyright © 2013 Samatov et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Samatov, Timur R
Tonevitsky, Alexander G
Schumacher, Udo
Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
title Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
title_full Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
title_fullStr Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
title_full_unstemmed Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
title_short Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
title_sort epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding rnas and modulating compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848796/
https://www.ncbi.nlm.nih.gov/pubmed/24053443
http://dx.doi.org/10.1186/1476-4598-12-107
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