Cargando…

Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25

BACKGROUND: HMLEs (HMLE-SNAIL and Kras-HMLE, Kras-HMLE-SNAIL pairs) serve as excellent model system to interrogate the effect of SNAIL targeted agents that reverse epithelial-to-mesenchymal transition (EMT). We had earlier developed a SNAIL-p53 interaction inhibitor (GN-25) that was shown to suppres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Azmi, Asfar S, Bollig-Fischer, Aliccia, Bao, Bin, Park, Bum-Joon, Lee, Sun-Hye, Yong-Song, Gyu, Dyson, Gregory, Reddy, Chandan K, Sarkar, Fazlul H, Mohammad, Ramzi M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848843/ https://www.ncbi.nlm.nih.gov/pubmed/24004452 http://dx.doi.org/10.1186/1752-0509-7-85

Ejemplares similares

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition
por: Azmi, Asfar S., et al.
Publicado: (2015)

Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4
por: Ahmad, Aamir, et al.
Publicado: (2015)

Obesity‐induced MBD2_v2 expression promotes tumor‐initiating triple‐negative breast cancer stem cells
por: Teslow, Emily A., et al.
Publicado: (2019)

Progress in Nanotechnology Based Approaches to Enhance the Potential of Chemopreventive Agents
por: Muqbil, Irfana, et al.
Publicado: (2011)

Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property
por: Azmi, Asfar S, et al.
Publicado: (2013)

Role of novel cancer gene SLITRK3 to activate NTRK3 in squamous cell lung cancer
por: Bollig-Fischer, Aliccia, et al.
Publicado: (2021)

Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer
por: Ayodeji, Saheed A., et al.
Publicado: (2023)

Treating triple negative breast cancer cells with erlotinib plus a select antioxidant overcomes drug resistance by targeting cancer cell heterogeneity
por: Bao, Bin, et al.
Publicado: (2017)

Pan-Bcl-2 Inhibitor AT-101 Enhances Tumor Cell Killing by EGFR Targeted T Cells
por: Thakur, Archana, et al.
Publicado: (2012)

Oncogene Activation Induces Metabolic Transformation Resulting in Insulin-Independence in Human Breast Cancer Cells
por: Bollig-Fischer, Aliccia, et al.
Publicado: (2011)

Exogenous IL‐6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild‐type, African American PCa cells
por: Teslow, Emily A., et al.
Publicado: (2018)

The Predominant Proteins that React to the MC-20 Estrogen Receptor Alpha Antibody Differ in Molecular Weight between the Mammary Gland and Uterus in the Mouse and Rat
por: Bollig-Fischer, Aliccia, et al.
Publicado: (2012)

(–)–Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice
por: Lee, Icksoo, et al.
Publicado: (2015)

MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy
por: Azmi, Asfar S., et al.
Publicado: (2010)

Detecting qualitative changes in biological systems
por: Mitrea, Cristina, et al.
Publicado: (2020)

Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics
por: Bollig-Fischer, Aliccia, et al.
Publicado: (2015)

Hypoxia Induced Aggressiveness of Prostate Cancer Cells Is Linked with Deregulated Expression of VEGF, IL-6 and miRNAs That Are Attenuated by CDF
por: Bao, Bin, et al.
Publicado: (2012)

Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice
por: Thakur, Archana, et al.
Publicado: (2008)

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors
por: Azmi, Asfar S., et al.
Publicado: (2011)

Amyloid-beta neuroprotection mediated by a targeted antioxidant
por: Giordano, Courtney R., et al.
Publicado: (2014)

Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways
por: Wang, Zhiwei, et al.
Publicado: (2011)

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy
por: Masood, Ashiq, et al.
Publicado: (2011)

Nuclear Export Inhibition for Pancreatic Cancer Therapy
por: Muqbil, Irfana, et al.
Publicado: (2018)

Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1
por: Michelhaugh, Sharon K, et al.
Publicado: (2015)

Network insights on oxaliplatin anti-cancer mechanisms
por: Alian, Osama M, et al.
Publicado: (2012)

Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment
por: Bao, Bin, et al.
Publicado: (2012)

Fibroblast Growth Factor Receptor 1 Amplification in Non-Small Cell Lung Cancer by Quantitative Real-Time PCR
por: Gadgeel, Shirish M., et al.
Publicado: (2013)

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
por: Liu, Gang, et al.
Publicado: (2009)

The Complexities of Epidemiology and Prevention of Gastrointestinal Cancers
por: Haq, Saba, et al.
Publicado: (2012)

Silencing Snail Reverses Epithelial-Mesenchymal Transition and Increases Radiosensitivity in Hypopharyngeal Carcinoma
por: Wang, HaiYan, et al.
Publicado: (2020)

The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma
por: Diab, Maria, et al.
Publicado: (2016)

Pre-clinical anti-tumor activity of Bruton's Tyrosine Kinase inhibitor in Hodgkin's Lymphoma cellular and subcutaneous tumor model
por: Muqbil, Irfana, et al.
Publicado: (2019)

Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT
por: Mitra, Shreya, et al.
Publicado: (2016)

DNA-Methylation-Caused Downregulation of miR-30 Contributes to the High Expression of XPO1 and the Aggressive Growth of Tumors in Pancreatic Ductal Adenocarcinoma
por: Azmi, Asfar S., et al.
Publicado: (2019)

Non-Coding RNAs in Pancreatic Cancer Diagnostics and Therapy: Focus on lncRNAs, circRNAs, and piRNAs
por: Li, Yiwei, et al.
Publicado: (2021)

Lichen Endozoochory by Snails
por: Boch, Steffen, et al.
Publicado: (2011)

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer
por: Ning, Changwen, et al.
Publicado: (2017)

Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer
por: Hojo, N., et al.
Publicado: (2018)

NF2 blocks Snail-mediated p53 suppression in mesothelioma
por: Cho, Jung-Hyun, et al.
Publicado: (2015)

Cancer cachexia research: coming of age
por: Muqbil, Irfana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ek3672e0rnbr0f2o6esdb24e06