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Bradykinin-induced Ca(2+) signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y(12) receptors activation

BACKGROUND: Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve changes in intracellular Ca(2+) ([Ca(2+)](i)). ATP has been related to connective tissue mechanotransduction, remodeling and chro...

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Detalles Bibliográficos
Autores principales:	Pinheiro, Ana Rita, Paramos-de-Carvalho, Diogo, Certal, Mariana, Costa, Cristina, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Costa, Maria Adelina, Correia-de-Sá, Paulo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848849/ https://www.ncbi.nlm.nih.gov/pubmed/24047499 http://dx.doi.org/10.1186/1478-811X-11-70

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