Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats

BACKGROUND: Intracellular calcium (Ca(2+)) coordinates the cardiac contraction cycle and is dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a divalent-copper-selective chelator, improves cardiac structure and function in patients and rats with diabetic cardiomyop...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Ward, Marie-Louise, Phillips, Anthony RJ, Zhang, Shaoping, Kennedy, John, Barry, Bernard, Cannell, Mark B, Cooper, Garth JS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848860/
https://www.ncbi.nlm.nih.gov/pubmed/23981320
http://dx.doi.org/10.1186/1475-2840-12-123

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