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The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans

Dendrites often adopt complex branched structures. The development and organization of these arbors fundamentally determine the potential input and connectivity of a given neuron. The cell-surface receptors that control dendritic branching remain poorly understood. Here, we show that in Caenorhabdit...

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Detalles Bibliográficos
Autores principales: Liu, Oliver W., Shen, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848871/
https://www.ncbi.nlm.nih.gov/pubmed/22138642
http://dx.doi.org/10.1038/nn.2978
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author Liu, Oliver W.
Shen, Kang
author_facet Liu, Oliver W.
Shen, Kang
author_sort Liu, Oliver W.
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description Dendrites often adopt complex branched structures. The development and organization of these arbors fundamentally determine the potential input and connectivity of a given neuron. The cell-surface receptors that control dendritic branching remain poorly understood. Here, we show that in Caenorhabditis elegans, a previously uncharacterized transmembrane protein containing extracellular leucine-rich repeat (LRR) domains, which we name DMA-1 (Dendrite-Morphogenesis-Abnormal), promotes dendrite branching and growth. Sustained expression of dma-1 is found only in the elaborately branched sensory neurons PVD and FLP. Genetic analysis showed that loss of dma-1 causes much reduced dendritic arbors while overexpression of dma-1 results in excessive branching. Forced expression of dma-1 in neurons with simple dendrites was sufficient to promote ectopic branching. Animals lacking dma-1 are defective in sensing harsh touch. DMA-1 is the first transmembrane LRR protein to be implicated in dendritic branching and expands the breadth of roles played by LRR receptors in nervous system development.
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spelling pubmed-38488712013-12-03 The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans Liu, Oliver W. Shen, Kang Nat Neurosci Article Dendrites often adopt complex branched structures. The development and organization of these arbors fundamentally determine the potential input and connectivity of a given neuron. The cell-surface receptors that control dendritic branching remain poorly understood. Here, we show that in Caenorhabditis elegans, a previously uncharacterized transmembrane protein containing extracellular leucine-rich repeat (LRR) domains, which we name DMA-1 (Dendrite-Morphogenesis-Abnormal), promotes dendrite branching and growth. Sustained expression of dma-1 is found only in the elaborately branched sensory neurons PVD and FLP. Genetic analysis showed that loss of dma-1 causes much reduced dendritic arbors while overexpression of dma-1 results in excessive branching. Forced expression of dma-1 in neurons with simple dendrites was sufficient to promote ectopic branching. Animals lacking dma-1 are defective in sensing harsh touch. DMA-1 is the first transmembrane LRR protein to be implicated in dendritic branching and expands the breadth of roles played by LRR receptors in nervous system development. 2011-12-04 /pmc/articles/PMC3848871/ /pubmed/22138642 http://dx.doi.org/10.1038/nn.2978 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Liu, Oliver W.
Shen, Kang
The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
title The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
title_full The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
title_fullStr The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
title_full_unstemmed The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
title_short The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
title_sort transmembrane leucine-rich repeat protein dma-1 promotes dendrite branching and growth in c. elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848871/
https://www.ncbi.nlm.nih.gov/pubmed/22138642
http://dx.doi.org/10.1038/nn.2978
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