Cargando…
Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
The translation of in vitro findings to clinical outcomes is often elusive. Trauma/hemorrhagic shock (T/HS) results in hepatic hypoxia that drives inflammation. We hypothesize that in silico methods would help bridge in vitro hepatocyte data and clinical T/HS, in which the liver is a primary site of...
Autores principales: | Ziraldo, Cordelia, Vodovotz, Yoram, Namas, Rami A., Almahmoud, Khalid, Tapias, Victor, Mi, Qi, Barclay, Derek, Jefferson, Bahiyyah S., Chen, Guoqiang, Billiar, Timothy R., Zamora, Ruben |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849193/ https://www.ncbi.nlm.nih.gov/pubmed/24312451 http://dx.doi.org/10.1371/journal.pone.0079804 |
Ejemplares similares
-
Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice
por: Namas, Rami A., et al.
Publicado: (2013) -
“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress
por: Vodovotz, Yoram, et al.
Publicado: (2017) -
Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
por: Zaaqoq, Akram M., et al.
Publicado: (2019) -
A Dynamic View of Trauma/Hemorrhage-Induced Inflammation in Mice: Principal Drivers and Networks
por: Mi, Qi, et al.
Publicado: (2011) -
A putative “chemokine switch” that regulates systemic acute inflammation in humans
por: Azhar, Nabil, et al.
Publicado: (2021)