iPSC-Based Cell Therapy: An Important Step Forward

Morizane et al. (2013) show that donor-matched differentiated derivatives of induced pluripotent stem cells (iPSC) do not cause an immune response after transplantation, whereas transplantation of HLA-mismatched iPSC derivatives to the same site clearly does. The importance of these results is discu...

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Detalles Bibliográficos
Autor principal: Rao, Mahendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849244/
https://www.ncbi.nlm.nih.gov/pubmed/24319663
http://dx.doi.org/10.1016/j.stemcr.2013.10.002
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author Rao, Mahendra
author_facet Rao, Mahendra
author_sort Rao, Mahendra
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description Morizane et al. (2013) show that donor-matched differentiated derivatives of induced pluripotent stem cells (iPSC) do not cause an immune response after transplantation, whereas transplantation of HLA-mismatched iPSC derivatives to the same site clearly does. The importance of these results is discussed in this commentary as we assess how best to move forward with iPSC-based cell therapy.
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spelling pubmed-38492442013-12-06 iPSC-Based Cell Therapy: An Important Step Forward Rao, Mahendra Stem Cell Reports Commentary Morizane et al. (2013) show that donor-matched differentiated derivatives of induced pluripotent stem cells (iPSC) do not cause an immune response after transplantation, whereas transplantation of HLA-mismatched iPSC derivatives to the same site clearly does. The importance of these results is discussed in this commentary as we assess how best to move forward with iPSC-based cell therapy. Elsevier 2013-10-15 /pmc/articles/PMC3849244/ /pubmed/24319663 http://dx.doi.org/10.1016/j.stemcr.2013.10.002 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Commentary
Rao, Mahendra
iPSC-Based Cell Therapy: An Important Step Forward
title iPSC-Based Cell Therapy: An Important Step Forward
title_full iPSC-Based Cell Therapy: An Important Step Forward
title_fullStr iPSC-Based Cell Therapy: An Important Step Forward
title_full_unstemmed iPSC-Based Cell Therapy: An Important Step Forward
title_short iPSC-Based Cell Therapy: An Important Step Forward
title_sort ipsc-based cell therapy: an important step forward
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849244/
https://www.ncbi.nlm.nih.gov/pubmed/24319663
http://dx.doi.org/10.1016/j.stemcr.2013.10.002
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