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Robust Self-Renewal of Rat Embryonic Stem Cells Requires Fine-Tuning of Glycogen Synthase Kinase-3 Inhibition

Germline-competent embryonic stem cells (ESCs) have been derived from mice and rats using culture conditions that include an inhibitor of glycogen synthase kinase 3 (GSK3). However, rat ESCs remain susceptible to sporadic differentiation. Here, we show that unsolicited differentiation is attributabl...

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Detalles Bibliográficos
Autores principales:	Chen, Yaoyao, Blair, Kathryn, Smith, Austin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849254/ https://www.ncbi.nlm.nih.gov/pubmed/24319657 http://dx.doi.org/10.1016/j.stemcr.2013.07.003

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